INT192291

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.02
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.93
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
plasma membrane (OR5A1) signal transducer activity (OR5A1)
Anatomy Link Frequency
cartilage 4
face 4
OR5A1 (Homo sapiens)
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 88 99.20 Very High Very High Very High
Arthritis 40 91.28 High High
cytokine 24 89.04 High High
Pain 8 57.80 Quite High
Osteoarthritis 24 55.72 Quite High
cINOD 16 5.00 Very Low Very Low Very Low
Acupuncture 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Onset of action 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 76 99.20 Very High Very High Very High
Arthritis 44 91.28 High High
Pain 4 57.80 Quite High
Osteoarthritis 28 55.72 Quite High
Inflammatory Bowel Disease 4 13.72 Low Low
Arthropathy 24 9.80 Low Low
Disease 12 5.00 Very Low Very Low Very Low
Reprotox - General 1 4 5.00 Very Low Very Low Very Low
Heart Disease 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The study had goals of determining if RNI 249 could activate human chondrocyte IGF-1 gene expression and maintain IGF-1 production in the face of pro-inflammatory signals, IL-1?
RNI 249 Positive_regulation (activate) of Gene_expression (expression) of IGF-1 gene in face associated with inflammation
1) Confidence 0.02 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.42 Pain Relevance 0.24
The study had goals of determining if RNI 249 could activate human chondrocyte IGF-1 gene expression and maintain IGF-1 production in the face of pro-inflammatory signals, IL-1?
RNI 249 Positive_regulation (maintain) of Gene_expression (production) of IGF-1 in face associated with inflammation
2) Confidence 0.02 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.42 Pain Relevance 0.24
The potential for RNI 249 to stimulate chondrocyte IGF-1 production was assessed by measurement of IGF-1 in the culture media of cartilage explants.
RNI 249 Positive_regulation (stimulate) of Gene_expression (production) of IGF-1 in cartilage
3) Confidence 0.02 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0 Pain Relevance 0
While RNI 249 stimulates basal IGF-1 gene expression and production in human cartilage, it was necessary to determine if this action was retained in the presence of IL-1?.
RNI 249 Positive_regulation (stimulates) of Gene_expression (expression) of IGF-1 gene in cartilage
4) Confidence 0.02 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.09 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox