INT192293

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1, IL1B) extracellular space (IGF1, IL1B) extracellular region (IGF1, IL1B)
cytosol (IL1B) aging (IL1B) cell-cell signaling (IL1B)
IGF1 (Homo sapiens)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 99.60 Very High Very High Very High
cytokine 6 63.28 Quite High
Inflammation 22 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Acupuncture 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Onset of action 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthropathy 6 75.92 Quite High
Disease 3 46.76 Quite Low
INFLAMMATION 19 5.00 Very Low Very Low Very Low
Arthritis 11 5.00 Very Low Very Low Very Low
Osteoarthritis 7 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Heart Disease 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Experimental Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They observed that by combining IGF-1 with an IL-1 receptor antagonist protein they could both increase proteoglycan production and decrease catabolism via reduced MMP synthesis.
IGF-1 Binding (combining) of IL-1 associated with antagonist
1) Confidence 0.15 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.08 Pain Relevance 0.08

General Comments

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