INT192298

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.71
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP7) extracellular space (MMP7) extracellular region (MMP7)
proteinaceous extracellular matrix (MMP7)
Anatomy Link Frequency
cartilage 2
chondrocytes 1
MMP7 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 142 100.00 Very High Very High Very High
Inflammation 114 99.90 Very High Very High Very High
Arthritis 100 94.88 High High
cytokine 26 93.76 High High
Onset of action 2 92.72 High High
Osteoarthritis 62 89.56 High High
rheumatoid arthritis 34 85.48 High High
Acupuncture 2 84.76 Quite High
cINOD 10 67.24 Quite High
Pain 8 45.24 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 114 99.90 Very High Very High Very High
Cancer 36 96.04 Very High Very High Very High
INFLAMMATION 96 95.68 Very High Very High Very High
Ovarian Cancer 92 91.76 High High
Wound Healing 14 91.64 High High
Osteoarthritis 66 89.56 High High
Rheumatoid Arthritis 34 85.48 High High
Toxicity 30 79.96 Quite High
Disease 41 74.32 Quite High
Heart Disease 2 70.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore intend to proceed with evaluation of MUC16, WFDC2, MSLN and MMP7, all of which have sensitivity >30% at 98% specificity in detection of clinically apparent serous cancers, beginning with analysis of serum specimens collected months to years prior to diagnosis of serous ovarian cancers.
Negative_regulation (evaluation) of MMP7 associated with cancer and ovarian cancer
1) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440813 Disease Relevance 1.02 Pain Relevance 0
These inhibitors have been shown to be selective for two relatively distinct repertoires of MMPs – whereas inhibitor II inhibits MMP-1, MMP-3, MMP-7 and MMP-9, inhibitor III blocks MMP-1, MMP-2, MMP-3, MMP-7 and MMP-13 [26].
Negative_regulation (blocks) of MMP-7 associated with metalloproteinase
2) Confidence 0.11 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779417 Disease Relevance 0.72 Pain Relevance 1.21
These inhibitors have been shown to be selective for two relatively distinct repertoires of MMPs – whereas inhibitor II inhibits MMP-1, MMP-3, MMP-7 and MMP-9, inhibitor III blocks MMP-1, MMP-2, MMP-3, MMP-7 and MMP-13 [26].
Negative_regulation (blocks) of MMP-7 associated with metalloproteinase
3) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779417 Disease Relevance 0.67 Pain Relevance 1.18
Joint inflammation and loss of cartilage matrix are not well correlated.
Negative_regulation (loss) of matrix in cartilage associated with inflammation and arthritis
4) Confidence 0.01 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.39 Pain Relevance 0.22
Glucosamine and chondroitin are structural elements of cartilage and matrix and their proposed therapeutic benefits center on the assumption that ingestion of these matrix elements, despite their poor absorption [14,15], will replace matrix that is lost as a result of the catabolic process.
Negative_regulation (lost) of matrix in cartilage
5) Confidence 0.01 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.54 Pain Relevance 0.39
g/ml, P < 0.01), a result that may suggest that direct inhibition of matrix metalloproteinases (Fig. 3).
Negative_regulation (inhibition) of matrix associated with metalloproteinase
6) Confidence 0.01 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1971260 Disease Relevance 0.10 Pain Relevance 0.14
Chondroprotective effects of a proanthocyanidin rich Amazonian genonutrient reflects direct inhibition of matrix metalloproteinases and upregulation of IGF-1 production by human chondrocytes

Background

Negative_regulation (inhibition) of matrix in chondrocytes associated with metalloproteinase
7) Confidence 0.01 Published 2007 Journal J Inflamm (Lond) Section Title Doc Link PMC1971260 Disease Relevance 0.26 Pain Relevance 0.13

General Comments

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