INT192299

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.24
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGFBP1) extracellular space (IGFBP1) extracellular region (IGFBP1)
IGFBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 88.00 High High
Inflammation 22 59.52 Quite High
Arthritis 10 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Acupuncture 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthropathy 6 89.96 High High
Aging 1 89.08 High High
INFLAMMATION 19 59.52 Quite High
Arthritis 11 5.00 Very Low Very Low Very Low
Osteoarthritis 7 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Hemorrhage 2 5.00 Very Low Very Low Very Low
Heart Disease 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 down-regulated the expression of IGFBP-1 mRNA in a time-dependent manner with a significant decrease observed at 48 h (p<0.01) and 72 h (p<0.001), as compared to time-matched controls (Figure 1A).
Regulation (regulated) of Gene_expression (expression) of IGFBP-1 mRNA
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
Altered production of IGF binding proteins that limit IGF functionality also contribute to the overall tone of the system [32,43,55-57].
Regulation (Altered) of Gene_expression (production) of binding
2) Confidence 0.00 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.24 Pain Relevance 0.10

General Comments

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