INT192300

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 12
Disease Relevance 2.85
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGFBP1) extracellular space (IGFBP1) extracellular region (IGFBP1)
Anatomy Link Frequency
cartilage 2
legs 2
IGFBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 58 99.98 Very High Very High Very High
rheumatoid arthritis 154 96.18 Very High Very High Very High
Inflammation 65 89.40 High High
Inflammatory marker 2 75.84 Quite High
antagonist 11 73.92 Quite High
tolerance 7 71.08 Quite High
cva 8 40.00 Quite Low
methotrexate 4 27.12 Quite Low
Dismenorea 7 19.20 Low Low
Pain 13 12.48 Low Low
Disease Link Frequency Relevance Heat
Acromegaly 83 99.28 Very High Very High Very High
Osteoarthritis 16 98.72 Very High Very High Very High
Critical Illness 2 98.52 Very High Very High Very High
Liver Disease 4 97.44 Very High Very High Very High
Obesity 28 96.74 Very High Very High Very High
Rheumatoid Arthritis 154 96.18 Very High Very High Very High
Arthropathy 18 89.64 High High
INFLAMMATION 63 89.40 High High
Aging 4 88.76 High High
Disorder Of Lipid Metabolism 8 85.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This change in cell shape is associated with rearrangements in cellular architecture, the accumulation of glycogen and increased expression of prolactin (PRL) and insulin growth factor binding protein 1 (IGFBP-1) [4], [5], [6].
Positive_regulation (accumulation) of Gene_expression (expression) of IGFBP-1
1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
This change in cell shape is associated with rearrangements in cellular architecture, the accumulation of glycogen and increased expression of prolactin (PRL) and insulin growth factor binding protein 1 (IGFBP-1) [4], [5], [6].
Positive_regulation (increased) of Gene_expression (expression) of insulin growth factor binding protein 1
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
1-induced suppression of IGFBP-1 is not SMAD-dependent and these data suggest that TGF?
Positive_regulation (induced) of Gene_expression (suppression) of IGFBP-1
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0.07
1 antibodies maintained expression of PRL mRNA (Figure 2A) and significantly potentiated expression of IGFBP-1 mRNA in comparison with ESCs treated with DM alone (p<0.001, Figure 2B).


Positive_regulation (potentiated) of Gene_expression (expression) of IGFBP-1 mRNA
4) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
1 on expression of PRL in ESCs but did not fully restore expression of IGFBP-1 mRNA and protein.


Neg (not) Positive_regulation (restore) of Gene_expression (expression) of IGFBP-1 mRNA
5) Confidence 0.40 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
1 increased expression of IGFBP-1 mRNA in decidualised cells.
Positive_regulation (increased) of Gene_expression (expression) of IGFBP-1 mRNA
6) Confidence 0.40 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
This change in cell shape is associated with rearrangements in cellular architecture, the accumulation of glycogen and increased expression of prolactin (PRL) and insulin growth factor binding protein 1 (IGFBP-1) [4], [5], [6].
Positive_regulation (increased) of Gene_expression (expression) of IGFBP-1
7) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
Similarly, cytokines upregulate IGFBP-1 synthesis [30].
Positive_regulation (upregulate) of Gene_expression (synthesis) of IGFBP-1 associated with cytokine
8) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 1.02 Pain Relevance 0.32
In this study, a well-characterized group of pre- and perimenopausal women with clinically and biochemically active RA, compared with age- and BMI-matched healthy women, exhibited reduced morning serum concentrations of IGF-I, a trend toward lower IGFBP-3, accelerated GH circulatory half-life, trends toward increases in IGFBP-1 and IL-6 levels (and total GH production), unaltered pulsatile, nycthemeral, or feedback-sensitive (entropic) features of cortisol or DHEA secretion, and substantially decreased LBM, especially in the legs.
Positive_regulation (increases) of Gene_expression (production) of IGFBP-1 in legs associated with obesity and rheumatoid arthritis
9) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.82 Pain Relevance 0.21
The concentration of IGFBP3, the main IGF carrier protein, is usually increased in patients with acromegaly, but this marker offers little further diagnostic information.


Positive_regulation (increased) of Gene_expression (concentration) of IGF carrier protein associated with acromegaly
10) Confidence 0.03 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459162 Disease Relevance 0.60 Pain Relevance 0.04
With the appreciation that increased levels of IGF-1 binding proteins have been observed in osteoarthritic cartilage [57] one needs to consider if the optimal approach is to raise circulating IGF-1 levels or alternatively promote local production in an autocrine manner.
Positive_regulation (increased) of Gene_expression (levels) of binding in cartilage associated with osteoarthritis
11) Confidence 0.00 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.16 Pain Relevance 0.06
Altered production of IGF binding proteins that limit IGF functionality also contribute to the overall tone of the system [32,43,55-57].
Positive_regulation (contribute) of Gene_expression (production) of binding
12) Confidence 0.00 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.24 Pain Relevance 0.11

General Comments

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