INT192309

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 4.54
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTM1, GSTT1) cytoplasm (GSTM1, GSTT1) small molecule metabolic process (GSTM1)
Anatomy Link Frequency
coronary artery 1
GSTM1 (Homo sapiens)
GSTT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 3 61.44 Quite High
Inflammation 2 30.84 Quite Low
drug abuse 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 201 99.78 Very High Very High Very High
Coronary Artery Disease 171 99.76 Very High Very High Very High
Cardiovascular Disease 12 95.72 Very High Very High Very High
Hypertension 20 84.72 Quite High
Diabetes Mellitus 22 83.60 Quite High
Cancer 26 83.04 Quite High
Dyslipidemia /

Combined Dyslipidemia

10 82.80 Quite High
Atherosclerosis 27 77.24 Quite High
Angina 3 61.44 Quite High
Increased Venous Pressure Under Development 13 58.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering the synergistic effects of GSTM1 null genotype and GSTT1 null genotype on risk of smoking-related CAD, we found that smokers with both GSTM1 and GSTT1 null genotype were at an approximately 2.76-fold higher risk of CAD than nonsmokers with both GSTM1 and GSTT1 positive genotype (CI, 1.17-6.52, p=0.04)
GSTM1 Binding (genotype) of GSTT1 associated with coronary artery disease and nicotine addiction
1) Confidence 0.43 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 2.36 Pain Relevance 0
So the aims of this study are to assess whether the GSTM1 and GSTT1 genotypes are associated with CAD, and to ascertain whether the risk of CAD given exposure to cigarette smoking is modified by the specific genetic polymorphisms of GSTM1 and GSTT1.


GSTM1 Binding (associated) of GSTT1 associated with nicotine addiction and coronary artery disease
2) Confidence 0.41 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 1.39 Pain Relevance 0.06
The association of the deletion in GSTT1 and GSTM1 genes with coronary artery disease (CAD) among smokers is controversial.
GSTM1 Binding (association) of GSTT1 in coronary artery associated with nicotine addiction and coronary artery disease
3) Confidence 0.37 Published 2006 Journal BMC Med Genet Section Abstract Doc Link PMC1458325 Disease Relevance 0.69 Pain Relevance 0

General Comments

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