INT192329

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PDGFRB) signal transducer activity (PDGFRB) ligase activity (UBR7)
signal transduction (PDGFRB) nucleus (PDGFRB) plasma membrane (PDGFRB)
Anatomy Link Frequency
fibroblasts 2
UBR7 (Homo sapiens)
PDGFRB (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 3 84.04 Quite High
fibrosis 27 59.36 Quite High
cytokine 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 9 59.36 Quite High
Cancer 6 42.96 Quite Low
Fibrosis 25 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Pathologic Processes 1 5.00 Very Low Very Low Very Low
Second Primary Neoplasms 1 5.00 Very Low Very Low Very Low
Immunotherapy Of Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fibroblasts, radiation markedly activated PDGF signaling as detected by enhanced PDGFR phosphorylation which was potently inhibited by SU9518.
SU9518 Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of PDGFR in fibroblasts
1) Confidence 0.01 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1458351 Disease Relevance 0.06 Pain Relevance 0.07

General Comments

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