INT192332

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.38
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TXK) nucleus (TXK) DNA binding (TXK)
molecular_function (UBR7) cytoplasm (TXK) ligase activity (UBR7)
Anatomy Link Frequency
endothelial cells 1
fibroblasts 1
UBR7 (Homo sapiens)
TXK (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 81 99.72 Very High Very High Very High
Inflammation 9 75.24 Quite High
cytokine 15 68.48 Quite High
corticosteroid 6 59.80 Quite High
cINOD 3 57.32 Quite High
Potency 9 57.16 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 27 99.72 Very High Very High Very High
Cancer 18 98.48 Very High Very High Very High
Fibrosis 75 97.78 Very High Very High Very High
INFLAMMATION 12 75.24 Quite High
Disease 12 64.72 Quite High
Repression 3 64.28 Quite High
Hyperplasia 3 7.08 Low Low
Pathologic Processes 3 5.00 Very Low Very Low Very Low
Second Primary Neoplasms 3 5.00 Very Low Very Low Very Low
Immunotherapy Of Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SU9518 exerts its inhibitory effect by ATP-competitive inhibition of the catalytic activity of the tyrosine kinase after PDGFR activation [32].
SU9518 Negative_regulation (inhibition) of tyrosine kinase
1) Confidence 0.00 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.84 Pain Relevance 0.40
In the context of fibrosis development in conventional cancer therapy, including radio- and chemotherapy, we studied here the effects of SU9518, a receptor tyrosine kinase inhibitor of PDGF signaling on human primary dermal fibroblasts and endothelial cells.
SU9518 Negative_regulation (inhibitor) of tyrosine kinase in fibroblasts associated with fibrosis and cancer
2) Confidence 0.00 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.27 Pain Relevance 0.11
In the context of fibrosis development in conventional cancer therapy, including radio- and chemotherapy, we studied here the effects of SU9518, a receptor tyrosine kinase inhibitor of PDGF signaling on human primary dermal fibroblasts and endothelial cells.
SU9518 Negative_regulation (inhibitor) of tyrosine kinase in endothelial cells associated with fibrosis and cancer
3) Confidence 0.00 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.27 Pain Relevance 0.11

General Comments

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