INT192337

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 10.34
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DDR1) cell adhesion (DDR1) plasma membrane (DDR1)
Anatomy Link Frequency
HGF 2
oligodendrocyte 2
chondrocytes 1
interstitial cells 1
DDR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 216 99.14 Very High Very High Very High
Osteoarthritis 135 97.56 Very High Very High Very High
Inflammation 34 91.68 High High
cytokine 28 88.96 High High
fibrosis 44 83.64 Quite High
metalloproteinase 16 79.16 Quite High
palliative 4 78.88 Quite High
Central nervous system 20 50.96 Quite High
Demyelination 6 39.92 Quite Low
Pain 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 2 100.00 Very High Very High Very High
Thyroid Neoplasm 161 99.92 Very High Very High Very High
Disease 154 99.64 Very High Very High Very High
Aging 84 99.16 Very High Very High Very High
Endometriosis 276 99.14 Very High Very High Very High
Stress 17 98.88 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2a 1 98.50 Very High Very High Very High
Osteoarthritis 135 97.56 Very High Very High Very High
Cancer 247 96.80 Very High Very High Very High
Gastrointestinal Stromal Tumor 106 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Besides having a strong target bias for C11Orf9, miR-199a-5p also has a significant bias for targetting DDR1, a tyrosine kinase receptor found to be upregulated during in vivo remyelination and in vitro oligodendrocyte differentiation [34].
Positive_regulation (upregulated) of DDR1 in oligodendrocyte
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864763 Disease Relevance 0.16 Pain Relevance 0
Like MRF, DDR1 has been shown to be upregulated during oligodendrocyte differentiation and remyelination [34].
Positive_regulation (upregulated) of DDR1 in oligodendrocyte
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864763 Disease Relevance 0 Pain Relevance 0.03
Therefore, DDR activation induced by ROS accumulation is now believed to be the hallmark of in vivo senescent tissues [22, 32].


Positive_regulation (activation) of DDR
3) Confidence 0.21 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.22 Pain Relevance 0.44
ROS production induces DDR-dependent premature senescence in preneoplasic cells and in OA chondrocytes contributing to the loss of their anabolic functions.
Positive_regulation (induces) of DDR in chondrocytes associated with aging and osteoarthritis
4) Confidence 0.20 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.19 Pain Relevance 0.33
ROS participated to the DNA damage accumulation and thereby to the activation of the DNA damage response (DDR) [4].
Positive_regulation (activation) of DDR
5) Confidence 0.19 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.20 Pain Relevance 0.38
Activated RTK phosphorylates numerous signaling molecules that initiate the intracellular signaling cascades leading to cell proliferation and survival [12].
Positive_regulation (Activated) of RTK
6) Confidence 0.08 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.67 Pain Relevance 0.24
The cumulative result of the point mutations associated with MEN 2A and 2B and FMTC and the chromosomal rearrangements associated with PTC is activation of the RET receptor tyrosine kinase (RTK).
Positive_regulation (activation) of RTK associated with multiple endocrine neoplasia type 2a and thyroid neoplasm
7) Confidence 0.06 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.05 Pain Relevance 0.10
However, except for a report showing an increase in c-Met (RTK) and HGF (ligand) in endometriosis [56], there has been little evidence that RTK are overexpressed or activated in this disease.


Neg (except) Positive_regulation (increase) of RTK in HGF associated with endometriosis and disease
8) Confidence 0.02 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.20 Pain Relevance 0.41
However, except for a report showing an increase in c-Met (RTK) and HGF (ligand) in endometriosis [56], there has been little evidence that RTK are overexpressed or activated in this disease.


Positive_regulation (activated) of RTK in HGF associated with endometriosis and disease
9) Confidence 0.02 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.21 Pain Relevance 0.42
can activate Rho-mediated signaling in HEK cells stably expressing the ovine FPA and FPB receptors and that this Rho signaling leads to the activation of focal adhesion kinase and the formation of actin stress fibers [15].
Positive_regulation (activation) of adhesion kinase associated with stress and adhesions
10) Confidence 0.02 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0.53 Pain Relevance 0
In this landmark publication, the group reported the finding of activating KIT mutations in a significant proportion of GISTs, with constitutive ligand-independent activation of the KIT-receptor tyrosine kinase (RTK), and a near universal expression of KIT on immunohistochemistry.7 Corroborated by Kindblom and others, it was demonstrated that GIST cells were closely related to the interstitial cells of Cajal.8 This understanding provided the platform for accurate and uniform diagnoses of this uncommon tumor and the rational development and use of tyrosine kinase inhibitors (TKI) in the management of GIST.


Neg (independent) Positive_regulation (activation) of RTK in interstitial cells associated with cancer and gastrointestinal stromal tumor
11) Confidence 0.01 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 1.47 Pain Relevance 0
Activated RTK phosphorylates numerous signaling molecules that initiate intracellular signaling cascades (Reviewed in Ref. [31]).
Positive_regulation (Activated) of RTK
12) Confidence 0.01 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.43 Pain Relevance 0.03

General Comments

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