INT192338

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.48
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDGFRB) cytoplasmic membrane-bounded vesicle (PDGFRB) plasma membrane (PDGFRB)
nucleus (PDGFRB) cytoplasm (PDGFRB) signal transducer activity (PDGFRB)
Anatomy Link Frequency
fibroblasts 2
PDGFRB (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 9 84.40 Quite High
fibrosis 81 59.72 Quite High
cytokine 15 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gastrointestinal Stromal Tumor 4 92.52 High High
Cancer 47 84.40 Quite High
Chromosome Aberrations 3 84.40 Quite High
Generaliased Trisomy 2 78.48 Quite High
Pulmonary Fibrosis 27 59.72 Quite High
Dermatofibrosarcoma 3 50.00 Quite Low
Ring Chromosomes 10 6.68 Low Low
Disease 29 6.24 Low Low
Fibrosis 75 5.00 Very Low Very Low Very Low
Metastasis 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, DFSP cells do not require high level of phosphorylation of PDGFRs and are ‘addicted’ to low levels of activation of receptor tyrosine kinases (Sirvent 2003).
Neg (not) Positive_regulation (require) of Phosphorylation (phosphorylation) of PDGFR
1) Confidence 0.45 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.42 Pain Relevance 0
Irradiation resulted in enhanced phosphorylation of PDGFR-?
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of PDGFR
2) Confidence 0.43 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0 Pain Relevance 0
In fibroblasts, radiation markedly activated PDGF signaling as detected by enhanced PDGFR phosphorylation which was potently inhibited by SU9518.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of PDGFR in fibroblasts
3) Confidence 0.43 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1458351 Disease Relevance 0.06 Pain Relevance 0.07
Irradiation resulted in enhanced phosphorylation of PDGFR-?
Positive_regulation (resulted) of Phosphorylation (phosphorylation) of PDGFR
4) Confidence 0.43 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0 Pain Relevance 0

General Comments

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