INT192339

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.02
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDGFRB) cytoplasmic membrane-bounded vesicle (PDGFRB) plasma membrane (PDGFRB)
nucleus (PDGFRB) cytoplasm (PDGFRB) signal transducer activity (PDGFRB)
PDGFRB (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 27 98.80 Very High Very High Very High
Potency 4 53.04 Quite High
cytokine 7 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 25 98.80 Very High Very High Very High
Pancreatic Cancer 69 92.20 High High
Hyperplasia 1 85.36 High High
Fatigue 2 85.00 Quite High
Cancer 40 78.16 Quite High
Disease 13 72.04 Quite High
Pulmonary Fibrosis 9 68.68 Quite High
Solid Tumor 3 61.80 Quite High
Glioblastoma 1 40.80 Quite Low
Sarcoma 2 39.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More importantly, for the ultimate goal of treating or preventing fibrosis in patients, we found that SU9518 attenuated the radiation-induced upregulation of PDGFR.
Positive_regulation (induced) of Positive_regulation (upregulation) of PDGFR associated with fibrosis
1) Confidence 0.46 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.53 Pain Relevance 0.12
Activation of PDGFR leads to downstream signal transduction via PI-3K, Phospholipase C?
Positive_regulation (leads) of Positive_regulation (Activation) of PDGFR
2) Confidence 0.36 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.49 Pain Relevance 0.03

General Comments

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