INT192340

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.83
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDGFRB) cytoplasmic membrane-bounded vesicle (PDGFRB) plasma membrane (PDGFRB)
nucleus (PDGFRB) cytoplasm (PDGFRB) signal transducer activity (PDGFRB)
Anatomy Link Frequency
fibroblasts 1
PDGFRB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 55.68 Quite High
nud 1 25.60 Quite Low
cytokine 6 8.52 Low Low
fibrosis 27 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
positron emission tomography 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioblastoma 18 98.80 Very High Very High Very High
Ovarian Cancer 103 97.84 Very High Very High Very High
Lung Cancer 7 97.00 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 87 95.40 Very High Very High Very High
Cancer 155 94.16 High High
Carcinoma 6 89.32 High High
Congenital Anomalies 1 88.60 High High
Vomiting 17 87.40 High High
Apoptosis 65 87.20 High High
Exanthema 6 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to our results, single radiation does not cause any changes in PDGFR ?
Neg (not) Regulation (changes) of PDGFR
1) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.74 Pain Relevance 0
We could show that there is no change in PDGFR ?
Neg (no) Regulation (change) of PDGFR
2) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.72 Pain Relevance 0
PDGFR protein regulation in fibroblasts
Regulation (regulation) of PDGFR in fibroblasts
3) Confidence 0.25 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0 Pain Relevance 0
Targeting the PDGF/PDGFR axis alone or in combination with classical chemotherapy is not very effective in the clinical setting.
Regulation (Targeting) of PDGFR
4) Confidence 0.22 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 0.88 Pain Relevance 0
To detect if changes in PDGFR ?
Regulation (changes) of PDGFR
5) Confidence 0.20 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.19 Pain Relevance 0
Sunitinib is an orally-active small molecule tyrosine kinase inhibitor that acts on multiple targets including VEGFR, PDGFR, c-kit and Flt-3.[46] In a phase II, open-label, multicenter study, sunitinib was evaluated as monotherapy in patients with MBC. 64 patients previously treated with an anthracycline and a taxane received sunitinib 50 mg daily in six week cycles, and results showed that 7 patients achieved a partial response with a median duration of 19 weeks giving an ORR of 11%. 3 patients achieved stable disease for greater than 6 months.
Regulation (targets) of PDGFR associated with disease and advanced or metastatic breast cancer
6) Confidence 0.14 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2579406 Disease Relevance 1.30 Pain Relevance 0.03

General Comments

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