INT192342

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Context Info
Confidence 0.80
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 1.68
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDGFRB) cytoplasmic membrane-bounded vesicle (PDGFRB) plasma membrane (PDGFRB)
nucleus (PDGFRB) cytoplasm (PDGFRB) signal transducer activity (PDGFRB)
Anatomy Link Frequency
fibroblasts 1
PDGFRB (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 243 98.16 Very High Very High Very High
cytokine 45 97.72 Very High Very High Very High
Potency 27 84.04 Quite High
Inflammation 27 5.00 Very Low Very Low Very Low
corticosteroid 18 5.00 Very Low Very Low Very Low
cINOD 9 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 49 98.30 Very High Very High Very High
Fibrosis 225 98.16 Very High Very High Very High
Gastrointestinal Stromal Tumor 4 91.64 High High
Pulmonary Fibrosis 81 86.88 High High
Chromosome Aberrations 3 84.40 Quite High
Cancer 96 83.52 Quite High
Generaliased Trisomy 2 78.48 Quite High
Apoptosis 19 73.92 Quite High
Pathologic Processes 9 67.72 Quite High
Dermatofibrosarcoma 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, DFSP cells do not require high level of phosphorylation of PDGFRs and are ‘addicted’ to low levels of activation of receptor tyrosine kinases (Sirvent 2003).
Phosphorylation (phosphorylation) of PDGFR
1) Confidence 0.80 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.41 Pain Relevance 0
It seems reasonable to assume that blocking phosphorylation of PDGFR could be a way of preventing biological effects of this cytokine and thus fibrogenesis.
Phosphorylation (phosphorylation) of PDGFR associated with fibrosis and cytokine
2) Confidence 0.76 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.62 Pain Relevance 0.28
Importantly, the autophosphorylation of PDGFR-?
Phosphorylation (autophosphorylation) of PDGFR
3) Confidence 0.66 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0 Pain Relevance 0
In fibroblasts, radiation markedly activated PDGF signaling as detected by enhanced PDGFR phosphorylation which was potently inhibited by SU9518.
Phosphorylation (phosphorylation) of PDGFR in fibroblasts
4) Confidence 0.58 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1458351 Disease Relevance 0.06 Pain Relevance 0.07
PDGFR levels as well as PDGFR phosphorylation were determined by western-blotting using primary antibodies specific to PDGFR-?
Phosphorylation (phosphorylation) of PDGFR
5) Confidence 0.58 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0 Pain Relevance 0
Irradiation resulted in enhanced phosphorylation of PDGFR-?
Phosphorylation (phosphorylation) of PDGFR
6) Confidence 0.58 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0 Pain Relevance 0
Importantly, RTK inhibitors could effectively attenuate this paracrine radiation-induced activation by blocking autophosphorylation of PDGFR and by downregulation of PDGFR expression.
Phosphorylation (autophosphorylation) of PDGFR
7) Confidence 0.58 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.28 Pain Relevance 0.08
phosphorylation while SU9518 treatment particularly inhibited phosphorylation of PDGFR-?.


Phosphorylation (phosphorylation) of PDGFR
8) Confidence 0.58 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0 Pain Relevance 0
PDGFR levels as well as PDGFR phosphorylation were determined by western-blotting using primary antibodies specific to PDGFR-?
Phosphorylation (phosphorylation) of PDGFR
9) Confidence 0.58 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0 Pain Relevance 0
Imatinib treatment combined with radiotherapy leads in breast cancer cell lines to a significant benefit which might be influenced through inhibition of PDGFR phosphorylation.
Phosphorylation (phosphorylation) of PDGFR associated with breast cancer
10) Confidence 0.53 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2925350 Disease Relevance 0.31 Pain Relevance 0
and anti-phosphorylated PDGFR-?
Phosphorylation (phosphorylated) of PDGFR
11) Confidence 0.51 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0 Pain Relevance 0

General Comments

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