INT192344

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Context Info
Confidence 0.54
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.26
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDGFRB) cytoplasmic membrane-bounded vesicle (PDGFRB) plasma membrane (PDGFRB)
nucleus (PDGFRB) cytoplasm (PDGFRB) signal transducer activity (PDGFRB)
PDGFRB (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 81 98.52 Very High Very High Very High
cytokine 15 97.72 Very High Very High Very High
Potency 9 11.64 Low Low
Inflammation 9 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 49 98.58 Very High Very High Very High
Fibrosis 75 98.52 Very High Very High Very High
Pulmonary Fibrosis 27 86.88 High High
Apoptosis 19 74.48 Quite High
Pathologic Processes 3 68.08 Quite High
Cancer 31 51.44 Quite High
Immunotherapy Of Cancer 5 42.12 Quite Low
Disease 12 40.48 Quite Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Glioblastoma 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It seems reasonable to assume that blocking phosphorylation of PDGFR could be a way of preventing biological effects of this cytokine and thus fibrogenesis.
Negative_regulation (blocking) of Phosphorylation (phosphorylation) of PDGFR associated with fibrosis and cytokine
1) Confidence 0.54 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.62 Pain Relevance 0.28
Importantly, RTK inhibitors could effectively attenuate this paracrine radiation-induced activation by blocking autophosphorylation of PDGFR and by downregulation of PDGFR expression.
Negative_regulation (blocking) of Phosphorylation (autophosphorylation) of PDGFR
2) Confidence 0.40 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.33 Pain Relevance 0.11
phosphorylation while SU9518 treatment particularly inhibited phosphorylation of PDGFR-?.


Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of PDGFR
3) Confidence 0.40 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0 Pain Relevance 0
Imatinib treatment combined with radiotherapy leads in breast cancer cell lines to a significant benefit which might be influenced through inhibition of PDGFR phosphorylation.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of PDGFR associated with breast cancer
4) Confidence 0.36 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2925350 Disease Relevance 0.31 Pain Relevance 0

General Comments

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