INT192348

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Context Info
Confidence 0.64
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.57
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDGFRB) cytoplasmic membrane-bounded vesicle (PDGFRB) plasma membrane (PDGFRB)
nucleus (PDGFRB) cytoplasm (PDGFRB) signal transducer activity (PDGFRB)
Anatomy Link Frequency
platelet 4
MCF 7 2
fibroblasts 2
PDGFRB (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 27 88.08 High High
nud 1 82.24 Quite High
Pain 16 67.60 Quite High
Analgesic 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chordoma 60 99.98 Very High Very High Very High
Breast Cancer 79 99.36 Very High Very High Very High
Sarcoma 9 99.36 Very High Very High Very High
Chronic Myeloid Leukemia 1 96.36 Very High Very High Very High
Cancer 93 88.68 High High
Fibrosis 25 88.08 High High
Disease 107 84.92 Quite High
Vomiting 5 83.92 Quite High
Dyspepsia 1 82.24 Quite High
Pulmonary Fibrosis 9 78.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the ultimate mechanism of PDGFR overexpression remains unclear, we found ionizing radiation can upregulate PDGFR in fibroblasts.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PDGFR in fibroblasts
1) Confidence 0.64 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.58 Pain Relevance 0.12
However, it is now evident that this agent has more than one target, including c-kit and PDGFR, which have been shown to be overexpressed in a subset of breast cancers and associated with poor prognosis [59].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PDGFR associated with breast cancer
2) Confidence 0.59 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.74 Pain Relevance 0.04
MCF 7 cells are positive for c-kit and PDGFR ?
Positive_regulation (for) of Gene_expression (positive) of PDGFR in MCF 7
3) Confidence 0.42 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.09 Pain Relevance 0
Chordoma overexpresses platelet-derived growth factor receptor (PDGFR)-?
Positive_regulation (overexpresses) of Gene_expression (overexpresses) of platelet-derived growth factor receptor in platelet associated with chordoma
4) Confidence 0.15 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2828414 Disease Relevance 1.08 Pain Relevance 0.07
Chordoma overexpresses platelet-derived growth factor receptor (PDGFR)-?
Positive_regulation (overexpresses) of Gene_expression (overexpresses) of PDGFR in platelet associated with chordoma
5) Confidence 0.15 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2828414 Disease Relevance 1.08 Pain Relevance 0.07

General Comments

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