INT192349

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.64
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PDGFB) cytoplasm (PDGFB)
Anatomy Link Frequency
epithelial cells 2
lung 2
PDGFB (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 78 99.92 Very High Very High Very High
Inflammation 24 99.28 Very High Very High Very High
chemokine 27 96.00 Very High Very High Very High
dexamethasone 3 88.80 High High
cytokine 34 88.00 High High
corticosteroid 2 66.12 Quite High
cINOD 4 63.64 Quite High
Inflammatory response 3 38.80 Quite Low
antagonist 6 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 33 99.92 Very High Very High Very High
INFLAMMATION 31 99.28 Very High Very High Very High
Fibrosis 82 99.08 Very High Very High Very High
Bronchopulmonary Dysplasia 3 95.12 Very High Very High Very High
Disease 17 85.24 High High
Repression 1 70.60 Quite High
Pneumonia 9 67.00 Quite High
Necrosis 3 59.56 Quite High
Cancer 133 59.20 Quite High
Radiation Sickness 6 36.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Savikko and his colleagues also showed that limiting the extent of inflammation by cyclosporin A treatment did not inhibit the expression of PDGF ligands and receptors [87].
Negative_regulation (inhibit) of Gene_expression (expression) of PDGF associated with inflammation
1) Confidence 0.31 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.59 Pain Relevance 0.18
Quantitative Real-time PCR confirmation of PDGF-BB induction
Negative_regulation (confirmation) of Gene_expression (induction) of PDGF-BB
2) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0 Pain Relevance 0.13
It has been suggested that pirfenidone and interferon gamma, both ameliorate lung fibrosis by downregulation of PDGF expression [72,90].
Negative_regulation (downregulation) of Gene_expression (expression) of PDGF in lung associated with fibrosis and pulmonary fibrosis
3) Confidence 0.23 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.29 Pain Relevance 0.18
Moreover, inhibiting the PDGF pathway with neutralising antibodies to PDGF or administration of soluble extracellular region of PDGFR-?
Negative_regulation (inhibiting) of Gene_expression (pathway) of PDGF
4) Confidence 0.23 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.92 Pain Relevance 0.34
But expression of c-sis mRNA in epithelial cells has been reported in certain pathologic fibrotic states, such as in patients with idiopathic lung fibrosis [21].
Negative_regulation (reported) of Gene_expression (expression) of c-sis mRNA in epithelial cells associated with fibrosis and pulmonary fibrosis
5) Confidence 0.06 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.83 Pain Relevance 0.42

General Comments

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