INT1924

Context Info Confidence 0.60 First Reported 1979 Last Reported 2010 Negated 2 Speculated 0 Reported most in Abstract Documents 11 Total Number 11 Disease Relevance 6.30 Pain Relevance 3.16

peptidase activity (PLAT) protein modification process (PLAT) extracellular space (PLAT) extracellular region (PLAT) cytoplasm (PLAT)

Anatomy Link Frequency plasma 1 synovium 1 PLAT (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 5 100.00 Osteoarthritis 5 99.46 qutenza 11 99.42 rheumatoid arthritis 5 99.06 palliative 3 98.00 Angina 22 97.92 Migraine 76 94.72 Pain 1 86.60 opioid receptor 6 85.40 metalloproteinase 14 83.20

Disease Link Frequency Relevance Heat Disease 16 99.68 Osteoarthritis 5 99.46 Coronary Artery Disease 19 99.32 Metastasis 4 99.28 Rheumatoid Arthritis 6 99.06 Leukemia 4 98.40 Cv General 3 Under Development 21 97.92 Advanced Or Metastatic Breast Cancer 4 97.52 Coronary Heart Disease 14 96.16 Headache 75 94.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

TPA antigen was affected to a similar extent by adjustment for parameters reflecting insulin resistance.

Regulation (affected) of TPA

1) Confidence 0.60 Published 1996 Journal Circulation Section Body Doc Link 8901651 Disease Relevance 0.05 Pain Relevance 0

Effect of heparin, aspirin, or alteplase in reduction of myocardial ischaemia in refractory unstable angina.

Regulation (Effect) of alteplase associated with aspirin, angina and coronary artery disease

2) Confidence 0.39 Published 1990 Journal Lancet Section Title Doc Link 1969013 Disease Relevance 0.51 Pain Relevance 0.50

The present study intended to clarify the effects of late thrombolysis with alteplase on left ventricular function parameters.

Regulation (effects) of alteplase

3) Confidence 0.39 Published 1996 Journal Rev Port Cardiol Section Abstract Doc Link 8763515 Disease Relevance 0.25 Pain Relevance 0.09

Tiaprofenic acid induced a dose-dependent decrease in uPA synthesis in both OA and RA, particularly in OA synovium, but had no true effect on tPA.

Neg (no) Regulation (effect) of tPA in synovium associated with rheumatoid arthritis and osteoarthritis

4) Confidence 0.32 Published 1992 Journal Br. J. Rheumatol. Section Abstract Doc Link 1555050 Disease Relevance 1.23 Pain Relevance 0.57

As no measurements of PAI-1 or t-PA activity were performed in our study, we cannot completely rule out an impaired endothelial fibrinolytic activity in patients with migraine.

Neg (no) Regulation (measurements) of t-PA associated with migraine

5) Confidence 0.30 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0.78 Pain Relevance 0.49

Results from the present study suggest that a combination of TPA and capsaicin may improve the therapeutic efficacy of TPA and overcome resistance to TPA in some myeloid leukemia patients.

Regulation (efficacy) of TPA associated with leukemia and qutenza

6) Confidence 0.24 Published 2005 Journal Int. J. Oncol. Section Abstract Doc Link 15645129 Disease Relevance 0.17 Pain Relevance 0.83

In another group of 39 patients with metastatic breast cancer who received palliative therapy, a limited correlation was noted between the clinical course of the disease and changes in TPA and CEA values measured in linear fashion.

Regulation (values) of TPA associated with disease, advanced or metastatic breast cancer and palliative

7) Confidence 0.23 Published 1979 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 292806 Disease Relevance 0.98 Pain Relevance 0.10

TPA was more sensitive but less specific than CEA; both provided almost identical discrimination.

Regulation (sensitive) of TPA

8) Confidence 0.17 Published 1983 Journal Cancer Detect. Prev. Section Abstract Doc Link 6197167 Disease Relevance 1.13 Pain Relevance 0.16

Independent of their orientation, these elements conferred TPA responsiveness on the heterologous thymidine kinase promoter.

Regulation (responsiveness) of TPA

9) Confidence 0.16 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11901219 Disease Relevance 0.08 Pain Relevance 0.27

A combined analysis of studies evaluating t-PA in coronary diseases, adjusted for some risk factors, suggests that CHD risk is about 50% greater in those with increased levels: a comparison of those in the top third with those in the bottom third of baseline t-PA antigen values yielded an odds ratio for CHD of 2.20 (1.70 – 2.85; 21 = 36) after adjustment for age and town only, and of 1.48 (1.09 – 2.01; 21 = 6) after further adjustment for classical CHD risk factors.36,37

Regulation (values) of t-PA associated with coronary heart disease

10) Confidence 0.11 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 0.51 Pain Relevance 0.06

The activity of t-PA in plasma is regulated by specific inhibitors.

Regulation (regulated) of t-PA in plasma

11) Confidence 0.07 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716784 Disease Relevance 0.60 Pain Relevance 0.11

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