INT192404

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 5.80
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighm)
Anatomy Link Frequency
B cells 2
natural killer cell 1
Ighm (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 106 99.84 Very High Very High Very High
Pain 77 87.60 High High
tolerance 5 76.00 Quite High
cytokine 106 70.36 Quite High
Pain management 6 63.44 Quite High
Arthritis 93 62.16 Quite High
Inflammation 78 56.48 Quite High
Inflammatory response 9 46.04 Quite Low
Lasting pain 25 32.16 Quite Low
Dorsal horn 1 31.32 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 106 99.84 Very High Very High Very High
Anaerobic Bacterial Infections 6 99.56 Very High Very High Very High
Epstein-barr Virus 93 96.38 Very High Very High Very High
Corneal Neovascularization 7 95.52 Very High Very High Very High
Breast Cancer 9 94.80 High High
Crystal Associated Disease 59 93.30 High High
Immunization 13 92.56 High High
Melanoma 18 92.40 High High
Autoimmune Disease 12 90.92 High High
Systemic Lupus Erythematosus 43 90.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the IgM-capture ELISA 50 µL of the 1?
Localization (capture) of IgM
1) Confidence 0.48 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2982812 Disease Relevance 0.69 Pain Relevance 0
Using this method, both anti-CCP IgG and anti-tetanus IgG as well as total IgM and IgG were found to be significantly enriched in RA synovia, whereas the value for RF-IgM did not differ significantly from 1.
Localization (enriched) of IgM associated with rheumatoid arthritis and anaerobic bacterial infections
2) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.50 Pain Relevance 0.17
IgG was detected very low in all the groups, and IgM's secreting was obviously increased by E2, CpG and E2 plus CpG (Figure 6).
Localization (secreting) of IgM
3) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0
ELISA for IgM secretion was performed as per manufacturer's protocol (Bethyl Laboratory).
Localization (secretion) of IgM
4) Confidence 0.37 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.08 Pain Relevance 0
For neutralizing antibody experiments the A4.1 anti-TSP-1 monoclonal antibody (Lab Vision, Fremont, CA) (CSVTCG/CD36) or control antibody (IgM) at 50 µg/mouse were administered intraperitoneally daily to PPAR?
Localization (administered) of IgM
5) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 0.75 Pain Relevance 0
Finally, analysis of the levels of secreted IgM in the tissue culture supernatants at 48 hours post-treatment or transfection demonstrated higher levels of secreted IgM in the M2 expressing and LPS treated cultures than in either the M2.Stop (vector) or untreated cultures (Fig. 6D).
Localization (secreted) of IgM
6) Confidence 0.33 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0 Pain Relevance 0
Finally, analysis of the levels of secreted IgM in the tissue culture supernatants at 48 hours post-treatment or transfection demonstrated higher levels of secreted IgM in the M2 expressing and LPS treated cultures than in either the M2.Stop (vector) or untreated cultures (Fig. 6D).
Localization (secreted) of IgM
7) Confidence 0.33 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.06 Pain Relevance 0
Secreted IgM levels remained similar throughout the time-course for M2 and control retrovirus B cell cultures (Figure 3C).
Localization (Secreted) of IgM in B cell
8) Confidence 0.22 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.07 Pain Relevance 0
With respect to antibodies, bovine grafts were less immunogenic than human grafts, but both photooxidized and unprocessed bovine grafts induced a late IgM response.
Localization (response) of IgM
9) Confidence 0.20 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0
EBV encodes a viral IL-10 homolog, BCRF1 (or vIL-10), that has been shown to increase human B cell proliferation following surface immunoglobulin crosslinkinking and induce B cells to secrete increased levels of IgM, IgG, and IgA in a similar manner to cellular IL-10 [17].
Localization (secrete) of IgM in B cells associated with epstein-barr virus
10) Confidence 0.19 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.63 Pain Relevance 0
IgM and IgG subclasses were detected using mouse immunoglobulin isotype specific monoclonal antibodies : anti-IgM IgG2a,?
Localization (subclasses) of IgM
11) Confidence 0.17 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0 Pain Relevance 0
BXD2 mice form spontaneous germinal centers which was IL-17-dependent, and treatment with IL-17 promoted the secretion of both IgM and IgG autoantibodies which was reduced by crossing BXD2 mice to IL-17R KO mice [27].
Localization (secretion) of IgM
12) Confidence 0.15 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.53 Pain Relevance 0.09
Anti-NGcGM3 IgM and IgG responses were detected in all patients who completed the first 5 injections, collectively termed as “induction phase”.
Localization (responses) of IgM
13) Confidence 0.10 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2965427 Disease Relevance 0.78 Pain Relevance 0.03
Following laughter or other humorous encounters, natural killer cell activity, immunoglobulin G and immunoglobulin M levels increase for as long as 12 hours [27, 28], and these evaluations bring about beneficial health outcomes.
Localization (increase) of immunoglobulin M in natural killer cell
14) Confidence 0.07 Published 2010 Journal Journal of Aging Research Section Body Doc Link PMC2989702 Disease Relevance 0.56 Pain Relevance 0.56
A Phase I study investigated the pharmacokinetics, pharmacodynamics, and safety of pegloticase by single subcutaneous injection in 13 subjects with TFG.43 It appeared that in 5 of 13 patients, the half-life of pegloticase was significantly lower than in the rest of the group and no measurable activity was present after 10 days, whereas in the other 8 patients, activity was still present after 21 days.43 The faster clearance in these 5 patients was demonstrated to be related to the presence of IgM and IgG antibodies against pegloticase.
Localization (presence) of IgM associated with crystal associated disease
15) Confidence 0.03 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988614 Disease Relevance 0.14 Pain Relevance 0

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