INT192406

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 5.58
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighm)
Anatomy Link Frequency
B-cell 1
lung 1
Ighm (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 17 96.88 Very High Very High Very High
Dismenorea 1 68.32 Quite High
tolerance 13 67.16 Quite High
Inflammation 72 57.84 Quite High
rheumatoid arthritis 62 57.28 Quite High
cytokine 107 56.80 Quite High
Arthritis 3 42.48 Quite Low
Osteoarthritis 22 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Viral Meningitis 233 99.72 Very High Very High Very High
Infection 187 98.90 Very High Very High Very High
Pneumonia 24 97.80 Very High Very High Very High
Coccidioides Infection 76 97.00 Very High Very High Very High
INFLAMMATION 78 96.52 Very High Very High Very High
Breast Cancer 8 94.80 High High
Immunization 54 92.56 High High
Dengue 115 92.08 High High
Influenza Virus Infection 8 86.16 High High
Cancer 64 86.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As for IgG, mouse to mouse variability in the IgM response was also observed.
Regulation (response) of IgM
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0.17 Pain Relevance 0
The PRNT50 titre range of the sera undetectable in IgM IIFT was 1?
Regulation (undetectable) of IgM IIFT
2) Confidence 0.29 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2982812 Disease Relevance 0 Pain Relevance 0
However, a single IgM positive result can also be confirmed by other techniques such as PRNT.
Regulation (confirmed) of IgM
3) Confidence 0.29 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2982812 Disease Relevance 0.64 Pain Relevance 0
In spite of this, however, the treatment did not have any effect on RF-IgM or anti-CCP IgG content in synovia with lymphoid aggregates, even though these tissues produced massively increased levels of autoantibodies compared with synovia with diffuse infiltration.
Regulation (effect) of IgM
4) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.05 Pain Relevance 0.03
In contrast to total protein and FITC-D, there were significant effects of both mechanical ventilation and genotype on BALF concentration of IgM (Figure 3D).
Regulation (effects) of IgM
5) Confidence 0.20 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0 Pain Relevance 0.03
Altogether only 33% of the vaccinated persons established an IgM response detectable in IIFT.
Regulation (response) of IgM
6) Confidence 0.18 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2982812 Disease Relevance 0.73 Pain Relevance 0
In addition, in figure 2 the OD values of both IgM ELISAs are compared to the corresponding PRNT50 results.
Regulation (values) of IgM
7) Confidence 0.18 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2982812 Disease Relevance 0.06 Pain Relevance 0
The course of the IgG and IgM response after JE vaccination was analyzed additionally.
Regulation (response) of IgM associated with viral meningitis
8) Confidence 0.18 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2982812 Disease Relevance 0.23 Pain Relevance 0
The course of the IgM and IgG response after JE vaccination was analysed in all vaccinees, therefore all PRNT50 positive and selected PRNT50 negative samples were assessed in IgM and IgG IIFT.
Regulation (response) of IgM associated with viral meningitis
9) Confidence 0.18 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2982812 Disease Relevance 0.62 Pain Relevance 0
–mediated IgM and IgG responses to soluble proteins (Le Bon et al., 2006).
Regulation (responses) of IgM
10) Confidence 0.14 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.20 Pain Relevance 0.06
Treated mice mounted an attenuated IgM response to the hapten oxazolone and produced no IgG antioxazolone antibodies.Anti-CD154 is a B-cell depleting therapy that affects multiple B-cell subsets.
Regulation (response) of IgM in B-cell
11) Confidence 0.08 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.12 Pain Relevance 0.03
With respect to antibodies, bovine grafts were less immunogenic than human grafts, but both photooxidized and unprocessed bovine grafts induced a late IgM response.
Regulation (response) of IgM
12) Confidence 0.07 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0
Therefore, attempts to detect recent RVFV infection by ELISA should include a combination of assays which target both viral antigens and IgM antibody.
Regulation (target) of IgM associated with infection
13) Confidence 0.05 Published 2010 Journal Veterinary Research Section Body Doc Link PMC2896810 Disease Relevance 0.59 Pain Relevance 0
Anti-NGcGM3 IgM and IgG responses were detected in all patients who completed the first 5 injections, collectively termed as “induction phase”.
Regulation (responses) of IgM
14) Confidence 0.03 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2965427 Disease Relevance 0.78 Pain Relevance 0.03
Hence, while there is lingering concern regarding the specificity of the Premier EIA, particularly the IgM (D Pappagianis, personal communication), published reports suggest that it is sensitive.
Regulation (regarding) of IgM
15) Confidence 0.03 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948390 Disease Relevance 0.37 Pain Relevance 0
Other evidence includes demonstration of a specific IgM response in the neonate27), radiographic changes indicative of pneumonia in culture-positive infants28), demonstration of the bacteria in lung tissue using immunofluorescence29), and electron microscopy27).

2.

Regulation (response) of IgM in lung associated with pneumonia
16) Confidence 0.02 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3021732 Disease Relevance 1.01 Pain Relevance 0.12

General Comments

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