INT192447

Context Info Confidence 0.44 First Reported 2006 Last Reported 2011 Negated 1 Speculated 0 Reported most in Body Documents 6 Total Number 8 Disease Relevance 2.32 Pain Relevance 0.29

cytosol (CLTC) mitosis (CLTC) mitochondrion (CLTC) vesicle-mediated transport (CLTC) structural molecule activity (CLTC) plasma membrane (CLTC)

Anatomy Link Frequency eye 1 tail 1 bone marrow 1 radial glial cells 1 CLTC (Homo sapiens)

Pain Link Frequency Relevance Heat alcohol 12 83.24 cva 12 82.72 ischemia 4 80.92 intrathecal 4 55.72 epidural 2 8.64 Pain 14 5.00 Central nervous system 9 5.00 anesthesia 6 5.00 drug abuse 6 5.00 Paracetamol 6 5.00

Disease Link Frequency Relevance Heat Toxicity 14 94.96 Fatty Liver 2 90.20 Death 6 87.04 Hepatotoxicity 14 86.80 Disease 246 86.04 Pressure And Volume Under Development 12 83.56 Hemorrhage 17 82.72 Increased Venous Pressure Under Development 6 82.24 Cv Unclassified Under Development 6 80.92 Liver Disease 2 74.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

They suggested the absence of CHC within serum to be due to the CHC not being released into the circulation as a bolus but rather via incremental leaching from the injection site – thus, the tiny volumes slowly released over the sampling period were below the 4 ng/mL test threshold.

Neg (not) Localization (released) of CHC

1) Confidence 0.44 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 0.22 Pain Relevance 0

The ability to localize the effect of injected CHC has been demonstrated by Badalamente and Hurst92 who injected CHC in vivo into anesthetized rat tail tendons and demonstrated that no adverse extravasation of CHCs (at doses between 150–300 U) occurred into adjacent muscle, nerve, other tendons, vessels, bone, or skin.

Localization (localize) of CHC in tail

2) Confidence 0.44 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 0.59 Pain Relevance 0.14

Because each fraction represented a roughly 15-day age cohort, this result suggests that the coefficient of variation of the HC distribution of RBCs released from the bone marrow must be much less than 3%, an amazing degree of uniformity for a process delivering 10 billion RBCs per hour to a healthy adult's circulation.

Localization (released) of HC in bone marrow

3) Confidence 0.16 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0 Pain Relevance 0

About 5% or less of the compounds in HC/ZnO smoke are released into the air as HC.

Localization (released) of HC

4) Confidence 0.12 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1459933 Disease Relevance 0.77 Pain Relevance 0.07

About 5% or less of the compounds in HC/ZnO smoke are released into the air as HC.

Localization (released) of HC

5) Confidence 0.11 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1459933 Disease Relevance 0.67 Pain Relevance 0.07

A significant difference was found between the widths of columns exhibiting high and low immunoreactivity, with stronger MHCI-HC staining intensity localized in the wider columns (Figure 10C).

Localization (localized) of MHCI-HC

6) Confidence 0.06 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0

In SWM, MHCI-HC protein colocalized with vimentin-positive radial glial cells.

Localization (colocalized) of MHCI-HC in radial glial cells

7) Confidence 0.06 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0

We used immunohistochemistry to localize the elevated MHCI-HC levels to neurons receiving afferent inputs from the intact eye.

Localization (localize) of MHCI-HC in eye

8) Confidence 0.06 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0.07 Pain Relevance 0

General Comments

This test has worked.