INT192447

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.32
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CLTC) mitosis (CLTC) mitochondrion (CLTC)
vesicle-mediated transport (CLTC) structural molecule activity (CLTC) plasma membrane (CLTC)
Anatomy Link Frequency
eye 1
tail 1
bone marrow 1
radial glial cells 1
CLTC (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 12 83.24 Quite High
cva 12 82.72 Quite High
ischemia 4 80.92 Quite High
intrathecal 4 55.72 Quite High
epidural 2 8.64 Low Low
Pain 14 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
drug abuse 6 5.00 Very Low Very Low Very Low
Paracetamol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 14 94.96 High High
Fatty Liver 2 90.20 High High
Death 6 87.04 High High
Hepatotoxicity 14 86.80 High High
Disease 246 86.04 High High
Pressure And Volume Under Development 12 83.56 Quite High
Hemorrhage 17 82.72 Quite High
Increased Venous Pressure Under Development 6 82.24 Quite High
Cv Unclassified Under Development 6 80.92 Quite High
Liver Disease 2 74.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They suggested the absence of CHC within serum to be due to the CHC not being released into the circulation as a bolus but rather via incremental leaching from the injection site – thus, the tiny volumes slowly released over the sampling period were below the 4 ng/mL test threshold.
Neg (not) Localization (released) of CHC
1) Confidence 0.44 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 0.22 Pain Relevance 0
The ability to localize the effect of injected CHC has been demonstrated by Badalamente and Hurst92 who injected CHC in vivo into anesthetized rat tail tendons and demonstrated that no adverse extravasation of CHCs (at doses between 150–300 U) occurred into adjacent muscle, nerve, other tendons, vessels, bone, or skin.
Localization (localize) of CHC in tail
2) Confidence 0.44 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 0.59 Pain Relevance 0.14
Because each fraction represented a roughly 15-day age cohort, this result suggests that the coefficient of variation of the HC distribution of RBCs released from the bone marrow must be much less than 3%, an amazing degree of uniformity for a process delivering 10 billion RBCs per hour to a healthy adult's circulation.



Localization (released) of HC in bone marrow
3) Confidence 0.16 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0 Pain Relevance 0
About 5% or less of the compounds in HC/ZnO smoke are released into the air as HC.
Localization (released) of HC
4) Confidence 0.12 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1459933 Disease Relevance 0.77 Pain Relevance 0.07
About 5% or less of the compounds in HC/ZnO smoke are released into the air as HC.
Localization (released) of HC
5) Confidence 0.11 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1459933 Disease Relevance 0.67 Pain Relevance 0.07
A significant difference was found between the widths of columns exhibiting high and low immunoreactivity, with stronger MHCI-HC staining intensity localized in the wider columns (Figure 10C).
Localization (localized) of MHCI-HC
6) Confidence 0.06 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
In SWM, MHCI-HC protein colocalized with vimentin-positive radial glial cells.
Localization (colocalized) of MHCI-HC in radial glial cells
7) Confidence 0.06 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
We used immunohistochemistry to localize the elevated MHCI-HC levels to neurons receiving afferent inputs from the intact eye.
Localization (localize) of MHCI-HC in eye
8) Confidence 0.06 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0.07 Pain Relevance 0

General Comments

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