INT192448

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 3.01
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CLTC) mitosis (CLTC) mitochondrion (CLTC)
vesicle-mediated transport (CLTC) structural molecule activity (CLTC) plasma membrane (CLTC)
Anatomy Link Frequency
eye 2
white matter 2
CLTC (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 6 98.92 Very High Very High Very High
cva 16 98.44 Very High Very High Very High
alcohol 10 73.32 Quite High
epidural 3 58.76 Quite High
reflex sympathetic dystrophy 6 52.92 Quite High
ischemia 6 47.20 Quite Low
Pain 21 37.16 Quite Low
Central nervous system 15 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 60 99.16 Very High Very High Very High
Hemorrhage 24 98.44 Very High Very High Very High
Disease 363 98.16 Very High Very High Very High
Paraplegia 3 97.60 Very High Very High Very High
Disease Susceptibility 9 97.52 Very High Very High Very High
Adhesions 5 96.04 Very High Very High Very High
Necrosis 4 90.92 High High
Toxicity 11 85.04 High High
Fatty Liver 1 80.28 Quite High
Increased Venous Pressure Under Development 9 80.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surgery is, however, likely to remain a valid treatment option, especially for recurrent cases following CHC injection, in patients with the aggressive form of the disease (strong diathesis), and in those patients with PIPJ involvement (which appears to not respond as favorably to the CHC-based technique when compared with simple MCPJ disease).
Positive_regulation (following) of Gene_expression (injection) of CHC associated with disease susceptibility and disease
1) Confidence 0.32 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 0.79 Pain Relevance 0
In another study, they showed that CHC injected epidurally resulted in local dural thinning at higher concentrations, whereas even small concentrations of CHC injected intrathecally resulted in intrathecal hemorrhage and acute paraplegia.
Positive_regulation (resulted) of Gene_expression (injected) of CHC associated with paraplegia, cva and intrathecal
2) Confidence 0.32 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 0.53 Pain Relevance 0.20
All patients had a single CHC injection, six into MCPJ and two into PIPJ; however, varying injection dosages were administered, and not all patients achieved the primary goal of extension to ?
Positive_regulation (single) of Gene_expression (injection) of CHC
3) Confidence 0.32 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 1.00 Pain Relevance 0.05
Animal studies have shown that hepatic tissues are moderately vulnerable to HC exposure, especially when exposure occurs by the oral route.
Positive_regulation (vulnerable) of Gene_expression (exposure) of HC
4) Confidence 0.07 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1459933 Disease Relevance 0.59 Pain Relevance 0.08
In situ hybridization also showed strong MHCI-HC gene expression in the subcortical white matter in the occipital lobes, consistent with previous studies on MHCI in the visual cortex of cats [15].
Positive_regulation (strong) of Gene_expression (expression) of MHCI-HC in white matter
5) Confidence 0.05 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
Neurons with higher MHCI-HC expression receive afferents from the intact eye
Positive_regulation (higher) of Gene_expression (expression) of MHCI-HC in eye
6) Confidence 0.04 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
Hence, in order to localize MHCI-HC expression in the V1 of the enucleated animals, we performed immunohistochemistry using the TP25.99 antibody.
Positive_regulation (localize) of Gene_expression (expression) of MHCI-HC
7) Confidence 0.04 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
In older animals (1 to 7 months of age), the signal became more diffuse, with cells in all cortical layers exhibiting MHCI-HC gene expression (Figure 2A and 2B).
Positive_regulation (exhibiting) of Gene_expression (expression) of MHCI-HC
8) Confidence 0.03 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
Interestingly, MHCI-HC transcript levels detected in the present study after monocular enucleation with qRT-PCR and in situ hybridization for classical marmoset MHCI-HC were also higher in response to monocular enucleation.
Positive_regulation (higher) of Gene_expression (detected) of MHCI-HC
9) Confidence 0.03 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0.10 Pain Relevance 0

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