INT192449

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Context Info
Confidence 0.23
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.57
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CLTC) mitosis (CLTC) mitochondrion (CLTC)
vesicle-mediated transport (CLTC) structural molecule activity (CLTC) plasma membrane (CLTC)
Anatomy Link Frequency
joint 1
synapses 1
CLTC (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 12 58.24 Quite High
drug abuse 6 57.36 Quite High
Pain 14 23.52 Low Low
cva 12 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Paracetamol 6 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
intrathecal 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 30 99.56 Very High Very High Very High
Adverse Drug Reaction 14 98.74 Very High Very High Very High
Hepatotoxicity 14 98.28 Very High Very High Very High
Toxicity 14 97.72 Very High Very High Very High
Disease 246 97.28 Very High Very High Very High
Contracture 50 97.26 Very High Very High Very High
Adult Respiratory Distress Syndrome 8 90.84 High High
Disease Susceptibility 6 86.08 High High
Recurrence 40 83.68 Quite High
Liver Disease 2 75.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CHC studies undertaken to date have clearly demonstrated that injection of CHC is a valid alternative to the traditional surgical options, despite neither treatment facilitating a definitive cure.
CHC Binding (injection) of
1) Confidence 0.23 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 0.78 Pain Relevance 0
The study end point was correction of metacarpophalangeal joint (MCPJ) or PIPJ fixed flexion contractures to full extension (0°–5°) and assessment of any related adverse reactions (see Figure 3 for an illustration of the anatomical landmarks associated with CHC in vivo injections).
CHC Binding (associated) of in joint associated with adverse drug reaction and contracture
2) Confidence 0.23 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 1.25 Pain Relevance 0
Several compounds, including ZnO, ZnCl2, HC, chlorinated vapors, and medications, may cause hepatic toxicity.
HC Binding (compounds) of associated with toxicity
3) Confidence 0.06 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1459933 Disease Relevance 0.72 Pain Relevance 0.03
Medical personnel, military and civilian alike, may be called upon to recognize and treat patients with HC/ZnO smoke injuries.
HC Binding (recognize) of associated with injury
4) Confidence 0.05 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1459933 Disease Relevance 0.82 Pain Relevance 0.06
The MHCI-HC molecules detected here with confocal microscopy and TP25.99 antibody seem to be associated with the postsynaptic sites (cell bodies and dendrites, Figure 5) and they displayed no obvious preference for excitatory vs inhibitory synapses (Additional file 3), as has previously been reported [23].


MHCI-HC Binding (associated) of in synapses
5) Confidence 0.03 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
Comparison of adjacent sections stained for MHCI-HC and c-Fos showed that the columns with high MHCI-HC immunoreactivity overlap with regions of high c-Fos immunoreactivity (Figure 9C and 9D and Additional file 6).
MHCI-HC Binding (immunoreactivity) of
6) Confidence 0.03 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0

General Comments

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