INT192494

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 2.26
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Crem) DNA binding (Crem)
Crem (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 6 95.28 Very High Very High Very High
depression 25 87.36 High High
Eae 35 78.08 Quite High
monoamine 4 76.84 Quite High
antidepressant 52 76.60 Quite High
Nucleus accumbens 25 71.76 Quite High
tricyclic antidepressant 5 68.40 Quite High
addiction 21 66.24 Quite High
Desipramine 11 61.60 Quite High
antagonist 15 47.72 Quite Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 1 96.04 Very High Very High Very High
Stress 124 94.48 High High
Herpes Simplex Virus 8 88.12 High High
Depression 29 87.36 High High
Targeted Disruption 146 86.24 High High
Disease 9 83.60 Quite High
Cancer 53 74.20 Quite High
Anxiety Disorder 60 69.60 Quite High
Suicidal Behaviour 8 68.24 Quite High
Drug Dependence 20 66.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Different ICER isoforms have different half-lives: ICER I is the most stable followed by ICER II, whereas ?
ICER II Binding (followed) of
1) Confidence 0.37 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0 Pain Relevance 0.04
It might also be the case that ICER-induced inhibition of transcription play a crucial role in “single-trial” or “sub-threshold” learning, but more robust repeated training (as in an odor discrimination task) is able to overcome the effects of loss or overexpression of ICER.
ICER-induced Neg (inhibition) Spec (might) Binding (inhibition) of
2) Confidence 0.37 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.25 Pain Relevance 0.03
Thus, ICER activation, by suppressing CRH transcription, serves as a protective mechanism helping to avoid the consequences of excessive expression of CRH [24, 25, 45].
ICER Binding (activation) of
3) Confidence 0.37 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.93 Pain Relevance 0.38
ICER is a transcription repressor, and after reaching a certain concentration, starts to suppress CRE-dependent activation of gene expression, including its own expression (through the formation of ICER homodimers or ICER-CREB heterodimers that bind to CREs and block transcription).
ICER Binding (bind) of
4) Confidence 0.36 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.09 Pain Relevance 0
ICER is a transcription repressor, and after reaching a certain concentration, starts to suppress CRE-dependent activation of gene expression, including its own expression (through the formation of ICER homodimers or ICER-CREB heterodimers that bind to CREs and block transcription).
ICER-CREB Binding (bind) of
5) Confidence 0.36 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.09 Pain Relevance 0
CREB belongs to the family of basic leucine zipper transcription factors and modulates gene transcription by binding to the cAMP responsive element (CRE) in the promoter regions of various genes[9].
cAMP responsive element Binding (binding) of
6) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.24 Pain Relevance 0.34
The system is based on the interaction between the tetracycline-responsive element (TRE), consisting of seven copies of the prokaryotic tetracycline operator site (tetO) fused to a cytomegalovirus minimal promoter region, and the reverse tetracycline-transactivator (rtTA), consisting of the prokaryotic tetracycline repressor protein (TetR) fused to the activator domain of the herpes simplex virus VP16 protein.
tetracycline-responsive element Binding (interaction) of associated with herpes simplex virus and cytomegalovirus infection
7) Confidence 0.00 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1463003 Disease Relevance 0.66 Pain Relevance 0

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