INT192536

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE6B) signal transduction (PDE6B)
Anatomy Link Frequency
photoreceptor 1
PDE6B (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 5.00 Very Low Very Low Very Low
vincristine 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 23 99.32 Very High Very High Very High
Infection 9 98.88 Very High Very High Very High
Solid Tumor 8 98.84 Very High Very High Very High
Retina Disease 13 97.96 Very High Very High Very High
Blindness 20 97.16 Very High Very High Very High
Neutropenia 72 81.04 Quite High
Breast Cancer 14 53.20 Quite High
Disease 17 52.64 Quite High
Fever 9 50.32 Quite High
Ocular Toxicity (including Many Sub-types) 11 48.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to improving RDI, G-CSF reduced the risk of infection-related mortality by 45% (1.5% vs. 2.8%: relative risk [RR] 0.55, 95% CI 0.33–0.90; p?
Gene_expression (improving) of RDI associated with infection
1) Confidence 0.65 Published 2010 Journal Support Care Cancer Section Body Doc Link PMC2846279 Disease Relevance 0.85 Pain Relevance 0
Mutations in the AIPL1 gene destabilize cGMP PDE and lead to photoreceptor dysfunction and a rapid retinal degeneration in mouse [8,9] and human [10].
Gene_expression (destabilize) of cGMP PDE in photoreceptor associated with retina disease
2) Confidence 0.41 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1463903 Disease Relevance 0.33 Pain Relevance 0

General Comments

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