INT192539

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.09
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GUCY2D)
Anatomy Link Frequency
photoreceptors 1
GUCY2D (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 58.44 Quite High
ketamine 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinal Diseases 14 98.00 Very High Very High Very High
Pseudolymphoma 1 96.60 Very High Very High Very High
Retina Disease 26 92.24 High High
Leber Congenital Amaurosis /

Leber Congenital Amaurosis

34 92.00 High High
Disease 33 89.88 High High
Plasmacytoma 21 87.52 High High
Multiple Myeloma 20 83.20 Quite High
Ocular Toxicity (including Many Sub-types) 22 77.72 Quite High
Blindness 40 68.80 Quite High
Inflammatory Bowel Disease 4 59.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical staining for most of the markers (CK, S-100, Vimentin, Desmin, LCA, CD 68, CD 3, CD 20 and Chromogranin) were negative.
Neg (negative) Gene_expression (negative) of LCA
1) Confidence 0.58 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1871591 Disease Relevance 0.38 Pain Relevance 0.06
This animal carries a deletion rearrangement in the gene encoding retGC1 that produces a null allele [11].
Gene_expression (produces) of retGC1
2) Confidence 0.50 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1463903 Disease Relevance 0.63 Pain Relevance 0
To test our hypothesis that vector-mediated expression of retGC1 in the photoreceptors of GUCY1*B chickens can restore photoreceptor function and sight in these animals, we adopted an in ovo treatment strategy that allowed us to treat the retina prior to the appearance of pathology in these cells.
Gene_expression (expression) of retGC1 in photoreceptors
3) Confidence 0.50 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1463903 Disease Relevance 0.50 Pain Relevance 0

General Comments

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