INT192540

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Context Info
Confidence 0.09
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.28
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CLTA) structural molecule activity (CLTA) plasma membrane (CLTA)
molecular_function (CLTA)
CLTA (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 8 69.68 Quite High
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leber Congenital Amaurosis /

Leber Congenital Amaurosis

96 100.00 Very High Very High Very High
Blindness 91 100.00 Very High Very High Very High
Retinal Diseases 15 78.08 Quite High
Frailty 3 56.32 Quite High
Photophobia 1 45.80 Quite Low
Congenital Anomalies 3 31.64 Quite Low
Disease 42 30.08 Quite Low
Retina Disease 29 25.00 Low Low
Bird Diseases 2 25.00 Low Low
Inborn Genetic Diseases 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LCA has previously been associated with mutations at nucleotide 9101 in the ATP synthase of the mitochondrion genome [22] as well as with mutation in another mitochondrial gene, NADH dehydrogenase subunit 4 [23].

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LCA Binding (associated) of associated with blindness
1) Confidence 0.09 Published 2007 Journal Proteome Sci Section Body Doc Link PMC1821315 Disease Relevance 0.20 Pain Relevance 0
Human RPE65-LCA has captured international interest as a potential target for a retinal gene therapy approach like that used in the RPE65-mutant dog [12,47].
LCA Binding (target) of
2) Confidence 0.05 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1896221 Disease Relevance 0.06 Pain Relevance 0.03
The Foundation for Retinal Research has detailed information on LCA

•?

LCA Binding (information) of
3) Confidence 0.02 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1463903 Disease Relevance 0.55 Pain Relevance 0
The Foundation Fighting Blindness funds research into, and provides information on, many types of blindness, including LCA

•?

LCA Binding (blindness) of associated with blindness
4) Confidence 0.02 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1463903 Disease Relevance 0.56 Pain Relevance 0

General Comments

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