INT192563

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.47
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HAT1) nucleolus (HAT1) nucleus (HAT1)
transferase activity, transferring acyl groups (HAT1) cytoplasm (HAT1)
Anatomy Link Frequency
nucleus 1
HAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 301 99.44 Very High Very High Very High
Inflammation 135 99.20 Very High Very High Very High
Osteoarthritis 149 98.28 Very High Very High Very High
metalloproteinase 17 94.12 High High
Arthritis 23 89.56 High High
cytokine 31 81.68 Quite High
Central nervous system 1 64.28 Quite High
Rheumatism 4 50.08 Quite High
agonist 1 50.00 Quite Low
Inflammatory mediators 8 49.36 Quite Low
Disease Link Frequency Relevance Heat
African Trypanosomiasis 187 100.00 Very High Very High Very High
Rheumatoid Arthritis 301 99.44 Very High Very High Very High
INFLAMMATION 157 99.20 Very High Very High Very High
Frailty 152 98.28 Very High Very High Very High
Cancer 38 93.84 High High
Arthritis 25 89.56 High High
Toxicity 24 84.56 Quite High
Repression 7 81.76 Quite High
Stress 7 77.76 Quite High
Disease 175 59.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Disability Adjusted Life Years (DALYs) for T. b. rhodesiense HAT
Gene_expression (b. rhodesiense) of HAT associated with african trypanosomiasis
1) Confidence 0.38 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970539 Disease Relevance 0.33 Pain Relevance 0
Turning to drugs, all the drugs used to treat HAT cases in Tanzania are provided free of charge by WHO.
Gene_expression (cases) of HAT associated with african trypanosomiasis
2) Confidence 0.38 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970539 Disease Relevance 0.17 Pain Relevance 0
In other words, FIND will create a network of public and private partners to produce new diagnostic tests for HAT and to demonstrate their effectiveness.
Gene_expression (produce) of HAT associated with african trypanosomiasis
3) Confidence 0.31 Published 2006 Journal Kinetoplastid Biol Dis Section Body Doc Link PMC1464096 Disease Relevance 0.41 Pain Relevance 0.03
treatment led to a marked increase in histone acetylation (Figure 8), consistent with HAT recruitment, H4 acetylation, and subsequent transcriptional activation [13].
Gene_expression (recruitment) of HAT
4) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.08 Pain Relevance 0
Measurement of HAT activity
Gene_expression (activity) of HAT
5) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.15 Pain Relevance 0.08
We examined HAT and HDAC activities in the total nuclear extracts of synovial tissues from RA patients predominantly treated with conventional DMARDs, and their relationship with the cytoplasmic level of TNF?.
Spec (examined) Gene_expression (activities) of HAT associated with rheumatoid arthritis
6) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.31 Pain Relevance 0.58
B binding (Esposito et al., 2008) and/or p300-HAT expression within the nucleus (Deng et al., 2006).
Gene_expression (expression) of HAT in nucleus
7) Confidence 0.04 Published 2008 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2993477 Disease Relevance 0.38 Pain Relevance 0.09
The HAT activity was expressed as arbitrary fluorescence units.
Gene_expression (expressed) of HAT
8) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.49 Pain Relevance 0.35
Total nuclear HAT activity was measured in synovial tissues from normal controls (7.04 ± 1.78 ?
Gene_expression (activity) of HAT
9) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.15 Pain Relevance 0.58

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