INT192564

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.77
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HAT1) nucleolus (HAT1) nucleus (HAT1)
transferase activity, transferring acyl groups (HAT1) cytoplasm (HAT1)
HAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 74 99.84 Very High Very High Very High
Osteoarthritis 36 99.68 Very High Very High Very High
Inflammation 41 98.98 Very High Very High Very High
cytokine 8 97.90 Very High Very High Very High
dexamethasone 2 93.04 High High
intrathecal 1 78.88 Quite High
corticosteroid 6 64.68 Quite High
cINOD 6 21.40 Low Low
Central nervous system 1 10.64 Low Low
Pain 1 8.76 Low Low
Disease Link Frequency Relevance Heat
African Trypanosomiasis 23 100.00 Very High Very High Very High
Rheumatoid Arthritis 75 99.84 Very High Very High Very High
Frailty 38 99.68 Very High Very High Very High
Asthma 53 99.52 Very High Very High Very High
INFLAMMATION 48 98.98 Very High Very High Very High
Repression 5 91.28 High High
Obesity 51 86.08 High High
Shock 2 78.48 Quite High
Infection 8 68.88 Quite High
Injury 3 64.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the extremely limited infrastructure in the settings in which HAT occurs however, there is still substantial progress to be made before NAA testing can be widely implemented as a diagnostic tool for HAT.
HAT Binding (tool) of associated with african trypanosomiasis
1) Confidence 0.15 Published 2006 Journal Kinetoplastid Biol Dis Section Body Doc Link PMC1464096 Disease Relevance 0.58 Pain Relevance 0.12
The level of HAT activity is elevated in patients with asthma, and HDAC activity is reduced in bronchial biopsies, which may contribute to local proinflammatory cytokine production.20 Glucocorticoids switch off inflammatory genes in those with asthma by directly inhibiting HAT activity and by recruiting HDAC2 to activate nuclear factor ?
HAT Binding (activity) of associated with asthma, inflammation and cytokine
2) Confidence 0.06 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2892049 Disease Relevance 0.69 Pain Relevance 0.25
In vitro studies suggest that HAT and HDACs can target several ?
HAT Binding (target) of
3) Confidence 0.03 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.11 Pain Relevance 0
These proteins either possess or recruit proteins with, histone acetyltransferase (HAT) activity allowing the RNA polymerase II complex to bind and initiate transcription of target genes [4, 7].
HAT Binding (bind) of
4) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.28 Pain Relevance 0.03
Measurement of HAT activity in RA, OA and normal synovial tissues
HAT Binding (activity) of associated with rheumatoid arthritis and osteoarthritis
5) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.13 Pain Relevance 0.56

General Comments

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