INT192611

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.86
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Hba-a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 6 5.00 Very Low Very Low Very Low
Botox 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 94.80 High High
Syndrome 48 92.28 High High
Thalassemia 42 86.24 High High
Apoptosis 2 73.44 Quite High
Cryptorchidism 8 72.44 Quite High
Urogenital Abnormalities 4 68.24 Quite High
Intellectual Impairment 28 53.60 Quite High
Leukemia 2 35.36 Quite Low
Congenital Anomalies 46 5.00 Very Low Very Low Very Low
Convulsion 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To date, no change in the pattern of methylation has been detected in the alpha globin gene cluster that might explain the reduced expression of the alpha globin genes compared with expression of the beta globin genes.
Negative_regulation (reduced) of Gene_expression (expression) of alpha globin
1) Confidence 0.07 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1464382 Disease Relevance 0.37 Pain Relevance 0
Thus, some patients do not have HbH inclusions [16,17,34], but this does not rule out down-regulation of alpha globin expression.
Negative_regulation (regulation) of Gene_expression (expression) of alpha globin
2) Confidence 0.05 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1464382 Disease Relevance 0.49 Pain Relevance 0

General Comments

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