INT192612

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.99
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Hba-a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 9 5.00 Very Low Very Low Very Low
Botox 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 72 92.28 High High
Thalassemia 63 89.52 High High
Cryptorchidism 12 72.44 Quite High
Urogenital Abnormalities 6 68.24 Quite High
Leukemia 3 58.80 Quite High
Intellectual Impairment 42 50.00 Quite Low
Disease 21 40.76 Quite Low
Congenital Anomalies 69 5.00 Very Low Very Low Very Low
Convulsion 27 5.00 Very Low Very Low Very Low
Muscle Hypotonia 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This variable frequency of cells with HbH inclusions indicates considerable variability in the degree to which alpha globin synthesis is affected by the 736C>T mutations.
Regulation (affected) of Gene_expression (synthesis) of alpha globin
1) Confidence 0.07 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1464382 Disease Relevance 0.44 Pain Relevance 0
Thus, some patients do not have HbH inclusions [16,17,34], but this does not rule out down-regulation of alpha globin expression.
Regulation (regulation) of Gene_expression (expression) of alpha globin
2) Confidence 0.05 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1464382 Disease Relevance 0.49 Pain Relevance 0
The function of the ATRX protein is unknown, but the fact that alpha globin expression is perturbed in the patients suggests that it may play a role in gene expression.
Regulation (perturbed) of Gene_expression (expression) of alpha globin
3) Confidence 0.05 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1464382 Disease Relevance 0.06 Pain Relevance 0

General Comments

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