INT192616

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.04
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Atrx) nucleus (Atrx) helicase activity (Atrx)
DNA binding (Atrx)
Atrx (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 9 5.00 Very Low Very Low Very Low
Botox 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 99.64 Very High Very High Very High
Syndrome 72 99.56 Very High Very High Very High
Intellectual Impairment 42 83.28 Quite High
Apoptosis 3 81.68 Quite High
Disease 21 78.20 Quite High
Thalassemia 63 76.40 Quite High
Leukemia 3 30.32 Quite Low
Congenital Anomalies 69 5.00 Very Low Very Low Very Low
Convulsion 27 5.00 Very Low Very Low Very Low
Muscle Hypotonia 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the knock-out mouse model, absence of ATRX is lethal early in embryogenesis indicating that ATRX is essential for development [29].
Negative_regulation (absence) of ATRX associated with targeted disruption
1) Confidence 0.43 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1464382 Disease Relevance 0.40 Pain Relevance 0
Most females who are unaffected carriers for ATR-X syndrome display preferential inactivation of the mutant ATRX allele [36].
Negative_regulation (inactivation) of ATRX associated with syndrome
2) Confidence 0.43 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1464382 Disease Relevance 0.37 Pain Relevance 0
Levels of ATRX protein were found to be substantially reduced in a number of patients with missense mutations involving the ADD domain [23,35].
Negative_regulation (reduced) of ATRX protein
3) Confidence 0.37 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1464382 Disease Relevance 0.28 Pain Relevance 0

General Comments

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