INT192631

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.34
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (XRCC2) DNA binding (XRCC2)
XRCC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 9 50.00 Quite Low
cINOD 22 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 2 100.00 Very High Very High Very High
Squamous Cell Carcinoma 4 84.04 Quite High
Skin Cancer 4 82.92 Quite High
Stress 5 77.28 Quite High
Apoptosis 43 50.00 Quite Low
Toxicity 18 50.00 Quite Low
Colon Cancer 9 50.00 Quite Low
Cancer 41 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was observed that a rad 51 paralogue XRCC2 irs1 line defective in homologous recombination (HR) shows significantly diminished caffeine radiosensitization which can be restored by expression of XRCC2 [1].
Gene_expression (expression) of XRCC2
1) Confidence 0.42 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1464387 Disease Relevance 0.17 Pain Relevance 0
As in yeast, rad51 paralogs (rad51b, rad51d, xrcc2 and xrcc3) that participate in HR in vertebrates were not found in E. histolytica (Table 1).
Gene_expression (paralogs) of xrcc2
2) Confidence 0.11 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
One microgram of RNA was reverse-transcribed into cDNA using iScript (BioRad, Hercules, CA), according to the manufacturer's instructions, and analyzed by real-time RT-PCR (MyiQ System, BioRad) to detect the expression of human breast cancer-resistance protein (BCRP-1), excision repair cross-complementing 1 and 2 (ERCC1-2), topoisomerase I (TOPO I), and thymidylate synthase (TYMS) chemosensitivity markers.
Spec (analyzed) Gene_expression (expression) of cross-complementing 1 and 2 associated with breast cancer
3) Confidence 0.10 Published 2007 Journal J Transl Med Section Body Doc Link PMC2174440 Disease Relevance 0.18 Pain Relevance 0

General Comments

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