INT192636

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.62
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

MORN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 84.04 Quite High
cytokine 6 83.16 Quite High
fibrosis 6 5.00 Very Low Very Low Very Low
Piles 3 5.00 Very Low Very Low Very Low
Restless leg syndrome 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 78 94.20 High High
Toxicity 54 92.52 High High
Hypoxia 9 87.72 High High
Fibrosis 9 84.56 Quite High
INFLAMMATION 6 84.04 Quite High
Cervical Cancer 9 44.72 Quite Low
Skin Cancer 12 31.76 Quite Low
Squamous Cell Carcinoma 12 30.96 Quite Low
Prostate Cancer 3 29.12 Quite Low
Vascular System Injuries 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The simplistic and widely accepted interpretation of this effect is that the drug abrogates the G2 block and promotes early mitosis thereby propagating DNA lesions.
Negative_regulation (abrogates) of G2 block
1) Confidence 0.01 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1464387 Disease Relevance 0.77 Pain Relevance 0.08
In p53 mutant cells irradiation induces a G2 block which is abrogated by Pentoxifylline.
Negative_regulation (abrogated) of G2 block
2) Confidence 0.01 Published 2006 Journal Radiat Oncol Section Abstract Doc Link PMC1464387 Disease Relevance 0.43 Pain Relevance 0
The additions were made either at the time of maximum G2 block expression or 7 hours later when the G2 block had been abrogated.
Negative_regulation (abrogated) of G2 block
3) Confidence 0.01 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1464387 Disease Relevance 0.42 Pain Relevance 0

General Comments

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