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Context Info
Confidence 0.59
First Reported 1989
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.62
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (AHSP) protein folding (AHSP) cytoplasm (AHSP)
Anatomy Link Frequency
vessels 2
endothelium 2
PGE2 2
AHSP (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 9 99.74 Very High Very High Very High
substance P 9 98.44 Very High Very High Very High
Calcitonin gene-related peptide 8 98.08 Very High Very High Very High
agonist 1 89.00 High High
Somatostatin 3 85.84 High High
Serotonin 3 85.44 High High
5HT 1 84.56 Quite High
Angina 1 82.96 Quite High
qutenza 5 80.48 Quite High
Dismenorea 1 48.60 Quite Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 2 92.44 High High
Stress 1 87.24 High High
Cv General 3 Under Development 1 82.96 Quite High
Coronary Vasospasm 2 82.12 Quite High
Hypoxia 2 64.80 Quite High
Dysmenorrhea 1 48.60 Quite Low
Premature Birth 1 41.72 Quite Low
Spontaneous Abortion 2 40.96 Quite Low
Nicotine Addiction 1 38.28 Quite Low
Coronary Artery Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In porcine coronary vessels the amount of EDRF released can be increased by a diet of codliver oil and decreased by a high cholesterol diet.
Negative_regulation (decreased) of Localization (released) of EDRF in vessels
1) Confidence 0.59 Published 1991 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 2038073 Disease Relevance 0.55 Pain Relevance 0.25
Therefore, nicotine prevents or abolishes the vasoconstrictive effects of PGE2 through the release of EDRF.
Negative_regulation (abolishes) of Localization (release) of EDRF in PGE2 associated with nicotine
2) Confidence 0.40 Published 1999 Journal Pharmacology Section Abstract Doc Link 9873232 Disease Relevance 0 Pain Relevance 0.35
Furthermore, pre-incubation with gossypol, an inhibitor of the formation and release of endothelium-derived relaxing factors (EDRF), completely abolished the effects of SP without influencing the dilatory action of CGRP.
Negative_regulation (inhibitor) of Localization (release) of EDRF in endothelium associated with calcitonin gene-related peptide and substance p
3) Confidence 0.32 Published 1989 Journal Acta Physiol. Scand. Section Abstract Doc Link 2476911 Disease Relevance 0.07 Pain Relevance 1.09

General Comments

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