INT192653

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 9.94
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Capns1) cytoplasm (Capns1)
Anatomy Link Frequency
skeletal muscle 1
Capns1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain scale 3 97.72 Very High Very High Very High
withdrawal 15 97.56 Very High Very High Very High
Inflammation 66 83.36 Quite High
antagonist 40 76.72 Quite High
ischemia 5 75.12 Quite High
corticosteroid 190 73.88 Quite High
peripheral neuropathy 5 71.84 Quite High
cva 12 51.16 Quite High
agonist 10 47.56 Quite Low
tolerance 20 38.40 Quite Low
Disease Link Frequency Relevance Heat
Syndrome 945 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 115 99.90 Very High Very High Very High
Vasculitis 16 98.56 Very High Very High Very High
Pain 23 97.48 Very High Very High Very High
Neuropathy 25 95.52 Very High Very High Very High
Hypersensitivity 42 94.40 High High
Insulin Resistance 5 92.88 High High
Exanthema 10 92.64 High High
Cicatrix 6 92.64 High High
Eosinophilia 55 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The association of the CSS total with the Role-emotional scale of the SF-36 was higher than previously reported [5].
CSS Binding (association) of
1) Confidence 0.26 Published 2006 Journal BMC Ear Nose Throat Disord Section Body Doc Link PMC1468424 Disease Relevance 0.32 Pain Relevance 0.10
The facilities and staffing level of non-private hospitals in developing countries make it often inevitable that CSs are associated with an appreciable mortality rate.
CSs Binding (associated) of
2) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556395 Disease Relevance 0.15 Pain Relevance 0
0.8, CssĀ»IC50
Css IC50 Binding (0.8) of
3) Confidence 0.09 Published 2008 Journal AAPS J Section Body Doc Link PMC2751452 Disease Relevance 0 Pain Relevance 0
The contractions of skeletal muscle are associated with calcium-dependent protease and calpain system 7, 8.
calcium-dependent protease Binding (associated) of in skeletal muscle
4) Confidence 0.06 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2536707 Disease Relevance 0.93 Pain Relevance 0
Multiple theories have been hypothesized to explain the possible linkage between CSS and the LTRAs, but no definitive causal link has been established.
CSS Binding (linkage) of associated with syndrome
5) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661620 Disease Relevance 1.63 Pain Relevance 0.10
Therefore, further investigation into the pathophysiologic linkage between CSS and use of LTRAs is necessary.
CSS Binding (linkage) of associated with syndrome
6) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661620 Disease Relevance 2.18 Pain Relevance 0.16
Approximately 10% of patients with severe vasculitis are recognized to have CSS.
CSS Binding (recognized) of associated with syndrome and increased venous pressure under development
7) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661620 Disease Relevance 1.92 Pain Relevance 0
To validate the postulated linkage between the LTRAs and CSS, this review comprehensively evaluates reported cases in the literature and supports a pathophysiological relationship between the LTRAs and the development of CSS.



CSS Spec (postulated) Binding (linkage) of associated with syndrome
8) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC1661620 Disease Relevance 1.04 Pain Relevance 0.12
If either formes frustes CSS (Churg et al 1995) or advanced CSS is diagnosed and the patient is taking a LTRA, discontinuing the LTRA is recommended until further research can exclude with confidence a definitive linkage in the evolution of CSS.
CSS Binding (linkage) of associated with syndrome
9) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661620 Disease Relevance 1.77 Pain Relevance 0.04

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