INT192686

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.66
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DMD) cytoskeleton (DMD) nucleus (DMD)
cytoplasm (DMD)
Anatomy Link Frequency
neck 2
hip 2
spine 2
femur 2
DMD (Homo sapiens)
Pain Link Frequency Relevance Heat
transdermal 24 97.88 Very High Very High Very High
spinal inflammation 60 97.84 Very High Very High Very High
withdrawal 3 89.20 High High
Inflammation 11 81.88 Quite High
rheumatoid arthritis 23 64.20 Quite High
headache 63 54.64 Quite High
cva 11 47.52 Quite Low
Osteoarthritis 19 36.88 Quite Low
Pain 42 5.00 Very Low Very Low Very Low
backache 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 135 100.00 Very High Very High Very High
Hypercalcemia 93 99.88 Very High Very High Very High
Ankylosis 3 99.08 Very High Very High Very High
Osteoporosis 341 97.88 Very High Very High Very High
Low Back Pain 74 97.84 Very High Very High Very High
Hip Fractures 18 95.48 Very High Very High Very High
Body Weight 6 82.32 Quite High
INFLAMMATION 12 81.88 Quite High
Frailty 35 76.92 Quite High
Aging 8 70.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preliminary analysis of LDD traits and LDD summary score showed significant correlations with age, weight and exercise, lumbar spine BMD and hip BMD (table 2, third column for each covariate, unadjusted R) and linear regression coefficients with BMD confirmed continuous and consistent increase of BMD measures as LDD increases (figure 1).
Positive_regulation (increases) of Positive_regulation (increase) of BMD in hip associated with disease
1) Confidence 0.41 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3002767 Disease Relevance 0.88 Pain Relevance 0
In a randomized study, it was shown that one year of brisk walking significantly increased calcaneal BMD and slightly increased spine BMD, although not significantly [20].
Positive_regulation (increased) of Positive_regulation (increased) of BMD in spine
2) Confidence 0.35 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022164 Disease Relevance 0 Pain Relevance 0
This study showed that sequential treatment of osteoporotic patients with PTH followed by alendronate results in a further increase in vertebral BMD that is significantly higher than BMD gained with PTH only and also with simultaneous alendronate and PTH.
Positive_regulation (followed) of Positive_regulation (increase) of BMD
3) Confidence 0.17 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936260 Disease Relevance 0.07 Pain Relevance 0.07
Previously, Bronson et al. showed that BMD was significantly lower at the femur neck but not the posteroanterior lumbar spine in patients with AS than in control subjects,22 and they suggested that ankylosis of the posterior elements of the spine might contribute to the false elevation of posteroanterior lumbar BMD measured by DXA.
Spec (might) Positive_regulation (contribute) of Positive_regulation (elevation) of BMD in femur associated with spinal inflammation and ankylosis
4) Confidence 0.12 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615310 Disease Relevance 1.36 Pain Relevance 0.55
These results suggest that cyclical etidronate may be beneficial in increasing the lumbar BMD and preventing vertebral fractures in patients with GIO.
Positive_regulation (beneficial) of Positive_regulation (increasing) of BMD associated with osteoporosis
5) Confidence 0.09 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815806 Disease Relevance 0.98 Pain Relevance 0.06
These results suggest that cyclical etidronate treatment may be effective for increasing the lumbar BMD and preventing vertebral fractures in patients with involutional osteoporosis.
Positive_regulation (effective) of Positive_regulation (increasing) of BMD associated with osteoporosis
6) Confidence 0.09 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815806 Disease Relevance 0.49 Pain Relevance 0
Most of the current findings suggest that the combination of two inhibitors of bone resorption results in a more pronounced decrease in bone resorption that induces a greater increase in BMD than either agent alone.
Positive_regulation (induces) of Positive_regulation (increase) of BMD associated with hypercalcemia
7) Confidence 0.05 Published 2008 Journal Osteoporos Int Section Body Doc Link PMC2613968 Disease Relevance 0.41 Pain Relevance 0
Measuring markers of bone turnover will increase our understanding of the mechanisms by which intermittent nitrates increase BMD (i.e. a decrease in bone resorption and/or an increase in bone formation).
Positive_regulation (increase) of Positive_regulation (increase) of BMD associated with hypercalcemia
8) Confidence 0.04 Published 2006 Journal Trials Section Body Doc Link PMC1471803 Disease Relevance 0.35 Pain Relevance 0.05
mg/d micronized progesterone resulted in similar increases in femur neck BMD (0.73% and 0.92%, respectively) after 18 months of treatment while the control group experienced a significant decrease in BMD (?
Positive_regulation (resulted) of Positive_regulation (increases) of BMD in neck
9) Confidence 0.03 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957171 Disease Relevance 0.11 Pain Relevance 0.20

General Comments

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