INT192761

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 7.45
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SAA1)
Anatomy Link Frequency
adipocytes 2
SAA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 122 99.82 Very High Very High Very High
Inflammation 139 99.00 Very High Very High Very High
Inflammatory mediators 16 97.24 Very High Very High Very High
Inflammatory marker 12 96.84 Very High Very High Very High
methotrexate 28 83.28 Quite High
rheumatoid arthritis 38 83.04 Quite High
Pain 13 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 162 99.84 Very High Very High Very High
Fever 182 99.58 Very High Very High Very High
Amyloidosis 93 99.52 Very High Very High Very High
INFLAMMATION 176 99.00 Very High Very High Very High
Syndrome 72 99.00 Very High Very High Very High
Periodontal Disease 20 94.40 High High
Disorder Of Lipid Metabolism 18 93.72 High High
Alzheimer's Dementia 51 93.56 High High
Infection 36 92.92 High High
Insulin Resistance 12 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sustained overproduction of SAA is a prerequisite for the development of AA amyloidosis, although the reasons for these remain unknown.
Positive_regulation (overproduction) of Gene_expression (overproduction) of SAA associated with amyloidosis
1) Confidence 0.40 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2911467 Disease Relevance 1.88 Pain Relevance 0.16
Sustained overproduction of SAA is a prerequisite for the development of AA amyloidosis.
Positive_regulation (overproduction) of Gene_expression (overproduction) of SAA associated with amyloidosis
2) Confidence 0.40 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2911467 Disease Relevance 1.71 Pain Relevance 0.24
The increased expression of A-SAA by adipocytes in obesity suggests that it may play a critical role in local and systemic inflammation and free fatty acid production and could be a direct link between obesity and its comorbidities, such as insulin resistance and atherosclerosis.
Positive_regulation (increased) of Gene_expression (expression) of SAA in adipocytes associated with inflammation, atherosclerosis, obesity and insulin resistance
3) Confidence 0.37 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1472697 Disease Relevance 2.09 Pain Relevance 0.24
Two notable exceptions were febrile patients P05 and P06 that did not have elevated WBC at the time of sampling even though the febrile episode was consistent with previous febrile attacks and CRP and SAA levels were elevated.
Positive_regulation (elevated) of Gene_expression (levels) of SAA associated with fever
4) Confidence 0.29 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.61 Pain Relevance 0
Worthy of note are the elevated levels of SAA in some afebrile PFAPA samples, suggesting that SAA is an extremely sensitive inflammatory marker.
Positive_regulation (elevated) of Gene_expression (levels) of SAA associated with inflammatory marker
5) Confidence 0.25 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.96 Pain Relevance 0.05
Based on these findings, it was confirmed that IL-6 is a cytokine that is indispensable for the production of CRP and SAA.
Positive_regulation (indispensable) of Gene_expression (production) of SAA associated with cytokine
6) Confidence 0.14 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0.20 Pain Relevance 0.13

General Comments

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