INT192765

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Context Info
Confidence 0.34
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 4.55
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SAA1)
Anatomy Link Frequency
adipocyte 2
SAA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 104 98.12 Very High Very High Very High
cytokine 38 72.56 Quite High
dexamethasone 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Weight Loss 42 99.16 Very High Very High Very High
Insulin Resistance 24 98.58 Very High Very High Very High
Obesity 324 98.56 Very High Very High Very High
INFLAMMATION 106 98.12 Very High Very High Very High
Atherosclerosis 10 94.16 High High
Diabetes Mellitus 14 89.44 High High
Hypertension 6 88.64 High High
Cardiovascular Disease 52 84.96 Quite High
Disease 6 83.04 Quite High
Stroke 6 79.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accordingly, improvements in systemic inflammation and insulin resistance with weight loss and rosiglitazone therapy may in part be mediated by decreases in adipocyte A-SAA production.


Negative_regulation (decreases) of Gene_expression (production) of SAA in adipocyte associated with weight loss, inflammation and insulin resistance
1) Confidence 0.34 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1472697 Disease Relevance 2.68 Pain Relevance 0.30
Serum A-SAA levels decreased significantly after weight loss in obese participants (

p = 0.006), as well as in those treated with rosiglitazone ( p = 0.033).

Negative_regulation (decreased) of Gene_expression (levels) of SAA associated with weight loss and obesity
2) Confidence 0.34 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1472697 Disease Relevance 1.86 Pain Relevance 0.24

General Comments

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