INT19277

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Context Info
Confidence 0.58
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 0.68
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Thra) mitochondrion (Thra) nucleus (Thra)
DNA binding (Thra) nucleic acid binding transcription factor activity (Thra) transcription factor binding (Thra)
Anatomy Link Frequency
neutrophil 2
neuronal 1
Thra (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 8 99.78 Very High Very High Very High
anesthesia 1 97.88 Very High Very High Very High
lidocaine 2 90.96 High High
guanethidine 1 86.72 High High
Clonidine 1 85.92 High High
agonist 2 84.76 Quite High
Rostral ventromedial medulla 1 84.12 Quite High
Rostral ventrolateral medulla 1 80.88 Quite High
medulla 2 79.64 Quite High
antagonist 4 76.12 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 1 86.32 High High
Pressure And Volume Under Development 7 83.12 Quite High
Hepatitis C Virus Infection 312 79.40 Quite High
Chronic Hepatitis 18 50.00 Quite Low
Fibrosis 24 43.08 Quite Low
Body Weight 30 42.40 Quite Low
Cirrhosis 72 31.00 Quite Low
Infection 18 5.00 Very Low Very Low Very Low
Obesity 12 5.00 Very Low Very Low Very Low
Hepatitis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The central and peripheral adrenergic-neuronal blocking agent reserpine has little or no clinical effect on GFR and ERPF/RBF; however, RVR is reduced.
Gene_expression (reduced) of RVR in neuronal
1) Confidence 0.58 Published 1985 Journal J Clin Hypertens Section Abstract Doc Link 2872278 Disease Relevance 0.08 Pain Relevance 0.33
Selective stimulation with microelectrodes increased RVR, MVR, and HQVR, with RVMM producing the strongest response in HQVR and RVLM the strongest effect on RVR.
Gene_expression (producing) of RVR
2) Confidence 0.55 Published 1988 Journal Clin Exp Hypertens A Section Abstract Doc Link 3242985 Disease Relevance 0 Pain Relevance 0.34
During administration of 0.8% isoflurane, amrinone produced decreases in IVR and RVR, which were more pronounced than the vasodilator responses induced by this dose of isoflurane alone.
Gene_expression (produced) of RVR associated with isoflurane
3) Confidence 0.54 Published 1991 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 2038924 Disease Relevance 0.09 Pain Relevance 0.43
The absence of any observable difference in haematologic side-effects between the RVR and non-RVR groups may be due to the smaller proportion of patients achieving RVR.
Gene_expression (groups) of RVR
4) Confidence 0.39 Published 2010 Journal Journal of Viral Hepatitis Section Body Doc Link PMC2810441 Disease Relevance 0.07 Pain Relevance 0
The absence of any observable difference in haematologic side-effects between the RVR and non-RVR groups may be due to the smaller proportion of patients achieving RVR.
Gene_expression (groups) of non-RVR
5) Confidence 0.39 Published 2010 Journal Journal of Viral Hepatitis Section Body Doc Link PMC2810441 Disease Relevance 0.07 Pain Relevance 0
In the RVR and non-RVR groups, mean changes in neutrophil counts at weeks 4 and 12 decreased from baseline to a similar extent with no difference observed between the groups.
Gene_expression (groups) of RVR in neutrophil
6) Confidence 0.39 Published 2010 Journal Journal of Viral Hepatitis Section Body Doc Link PMC2810441 Disease Relevance 0.05 Pain Relevance 0
While there was no difference in haematologic response between the RVR and non-RVR groups, significantly greater decreases in haematologic parameters at week 12 were shown in patients who achieved cEVR when compared with those patients who did not achieve cEVR.
Gene_expression (groups) of RVR
7) Confidence 0.39 Published 2010 Journal Journal of Viral Hepatitis Section Body Doc Link PMC2810441 Disease Relevance 0.13 Pain Relevance 0
In the RVR and non-RVR groups, mean changes in neutrophil counts at weeks 4 and 12 decreased from baseline to a similar extent with no difference observed between the groups.
Gene_expression (groups) of non-RVR in neutrophil
8) Confidence 0.39 Published 2010 Journal Journal of Viral Hepatitis Section Body Doc Link PMC2810441 Disease Relevance 0.05 Pain Relevance 0
While there was no difference in haematologic response between the RVR and non-RVR groups, significantly greater decreases in haematologic parameters at week 12 were shown in patients who achieved cEVR when compared with those patients who did not achieve cEVR.
Gene_expression (groups) of non-RVR
9) Confidence 0.39 Published 2010 Journal Journal of Viral Hepatitis Section Body Doc Link PMC2810441 Disease Relevance 0.13 Pain Relevance 0

General Comments

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