INT192785

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 9.05
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Myo5a) Golgi apparatus (Myo5a) cytoplasm (Myo5a)
Anatomy Link Frequency
lungs 2
liver 1
arms 1
respiratory 1
Myo5a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 188 97.84 Very High Very High Very High
chemokine 15 89.68 High High
Inflammatory response 6 81.12 Quite High
Inflammatory mediators 24 80.80 Quite High
cytokine 10 70.48 Quite High
rheumatoid arthritis 1 54.80 Quite High
Central nervous system 1 48.56 Quite Low
fibrosis 3 19.52 Low Low
anakinra 2 11.68 Low Low
imagery 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 60 100.00 Very High Very High Very High
Mevalonate Kinase Deficiency 38 100.00 Very High Very High Very High
Malaria 32 99.80 Very High Very High Very High
Chromosome Aberrations 1 99.04 Very High Very High Very High
Failure To Thrive 4 98.82 Very High Very High Very High
Anaemia 3 98.30 Very High Very High Very High
Lymphadenopathy 4 98.14 Very High Very High Very High
INFLAMMATION 214 97.84 Very High Very High Very High
Liver Disease 2 97.80 Very High Very High Very High
Infection 76 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results revealed that azithromycin had no effect on SeV viral kinetics in the lung tissue at day 5 and 8 post-viral inoculation, time points that corresponded to the peak of viral load in the lungs and virus clearance respectively [31].
Neg (no) Regulation (effect) of SeV in lungs
1) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2906448 Disease Relevance 1.46 Pain Relevance 0.25
To investigate whether azithromycin had an effect on SeV burden in the lung tissue, we quantified SeV-specific RNA at day 5 and 8 post-viral inoculation.
Spec (whether) Regulation (effect) of SeV in lung
2) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2906448 Disease Relevance 0.59 Pain Relevance 0.30
Future studies will be required to determine if different treatment regimens, such as initiation of treatment a few days after inoculation or alternate dosing regimens would result in a similar beneficial treatment effect on SeV as well as other respiratory viruses.
Regulation (effect) of SeV in respiratory
3) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2906448 Disease Relevance 1.45 Pain Relevance 0.35
The constellation of congenital malformations, hepatosplenomegaly, cholestatic liver disease, lymphadenopathy, anemia, severe failure to thrive and developmental retardation, which is found in severely affected MVA patients might suggest chromosomal aberrations or congenital infections.
Regulation (affected) of MVA in liver associated with chromosome aberrations, liver disease, mevalonate kinase deficiency, anaemia, failure to thrive, lymphadenopathy and infection
4) Confidence 0.03 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1475558 Disease Relevance 3.21 Pain Relevance 0.03
This trial is the first to evaluate clinically the combined administration of two promising malaria vaccines targeting different life-cycle stages: FP9/MVA ME-TRAP and PEV3A.
Regulation (targeting) of MVA ME-TRAP associated with malaria
5) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2204057 Disease Relevance 0.99 Pain Relevance 0
In the flail arm variant (which also is known as the Vulpian-Bernhardt syndrome [60] and Brachial amyotrophic diplegia [61]), weakness and wasting predominantly affects the proximal upper limb in a symmetrical pattern, leading to severe wasting around the shoulder girdle and the arms hanging flaccidly either side.
Regulation (affects) of flail in arms associated with syndrome
6) Confidence 0.02 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 1.35 Pain Relevance 0

General Comments

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