INT192786

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Context Info
Confidence 0.11
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.26
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
memory B cell 2
Ighd (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 22 53.44 Quite High
cINOD 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
anakinra 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mevalonate Kinase Deficiency 38 95.72 Very High Very High Very High
Syndrome 35 94.56 High High
Epilepsy 3 89.92 High High
Ataxia 8 88.72 High High
Intellectual Impairment 3 88.40 High High
Congenital Anomalies 8 86.60 High High
Fever 21 82.92 Quite High
Disease 6 81.68 Quite High
Arthralgia 4 79.84 Quite High
Lymphadenopathy 4 78.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased levels of immunoglobulin D (IgD) and, in most patients of immunoglobulin A (IgA), in combination with enhanced excretion of mevalonic acid provide strong evidence for HIDS.
Positive_regulation (Increased) of Gene_expression (levels) of IgD associated with syndrome
1) Confidence 0.11 Published 2006 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1475558 Disease Relevance 2.21 Pain Relevance 0
Together, these data provide strong evidence that M2 expression leads to B cell activation and differentiation similar to a functional activated, pre-plasma memory B cell phenotype, namely CD19+, sIgG+, sIgD?
Positive_regulation (activated) of Gene_expression (phenotype) of sIgD in memory B cell
2) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.05 Pain Relevance 0.05

General Comments

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