INT19279

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Context Info
Confidence 0.43
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.62
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 5 100.00 Very High Very High Very High
cytokine 24 91.20 High High
Arthritis 20 85.16 High High
Calcium channel 4 75.00 Quite High
iatrogenic 1 61.00 Quite High
Inflammation 42 50.00 Quite Low
addiction 1 49.96 Quite Low
opiate 1 25.36 Quite Low
potassium channel 1 25.00 Low Low
Bioavailability 8 11.24 Low Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 2 92.12 High High
Chronic Myeloid Leukemia 2 91.92 High High
Pressure And Volume Under Development 10 87.28 High High
Arthritis 20 85.16 High High
Disease 10 84.24 Quite High
Nephrotoxicity 2 83.56 Quite High
Experimental Arthritis 2 83.08 Quite High
Organ Transplantation 11 75.00 Quite High
Hyperplasia 1 68.08 Quite High
Hypertension 3 65.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This additive immunosuppression was not likely to have been related to these drugs' effects on interleukin-2 (IL-2) circuitry, since no additive inhibition of IL-2 production or IL-2 responsiveness was found.
Negative_regulation (inhibition) of Negative_regulation (responsiveness) of IL-2
1) Confidence 0.43 Published 1991 Journal Am. J. Med. Section Abstract Doc Link 2039018 Disease Relevance 0.46 Pain Relevance 0.14
Production of IL-2 was suppressed by 0.1-100 microM of heroin, whereas exposure to methadone appeared to result in a generalized modulation, with suppression of IL-2 at most concentrations.
Negative_regulation (suppressed) of Negative_regulation (suppression) of IL-2 associated with methadone
2) Confidence 0.42 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7713351 Disease Relevance 0.07 Pain Relevance 0.42
In an ex vivo anti-CD3/CD-28-induced IL-2 production model in mice, orally administered 23 reduced serum IL-2 levels in a dose-dependent manner with ED50?
Negative_regulation (administered) of Negative_regulation (levels) of IL-2
3) Confidence 0.03 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.60 Pain Relevance 0.08
55) and was orally efficacious in reducing serum levels of IL-2 in BALB/c mice with ED50?
Negative_regulation (reducing) of Negative_regulation (reducing) of IL-2
4) Confidence 0.03 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.49 Pain Relevance 0.15

General Comments

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