INT1928

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Context Info
Confidence 0.51
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 11.22
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lpl) extracellular region (Lpl) plasma membrane (Lpl)
Anatomy Link Frequency
fat 3
skeletal muscle 3
PIMs 1
adipose tissue 1
Lpl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
beta blocker 2 99.68 Very High Very High Very High
anesthesia 3 99.60 Very High Very High Very High
halothane 1 99.38 Very High Very High Very High
cytokine 21 99.32 Very High Very High Very High
antagonist 7 97.68 Very High Very High Very High
abdominal pain 4 96.64 Very High Very High Very High
Chronic pancreatitis 10 93.28 High High
agonist 50 92.56 High High
Pain 2 88.80 High High
Bile 1 88.24 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 43 100.00 Very High Very High Very High
Acute Necrotizing Pancreatitis 1 99.66 Very High Very High Very High
Disease 8 99.36 Very High Very High Very High
Obesity 53 99.24 Very High Very High Very High
Pancreatitis 29 99.06 Very High Very High Very High
Syndrome 20 98.80 Very High Very High Very High
Diabetes Mellitus 158 97.12 Very High Very High Very High
Metabolic Syndrome 149 96.84 Very High Very High Very High
Abdominal Pain 4 96.64 Very High Very High Very High
Body Weight 13 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another mechanism that could explain the effect of TV viewing on metabolic syndrome, could be that physical inactivity would reduce the triglyceride uptake from plasma to muscle and it would further lower serum HDL concentrations due to the decrease of lipoprotein lipase (LPL) activity in the skeletal muscle [48].
Negative_regulation (decrease) of lipoprotein lipase in skeletal muscle associated with metabolic syndrome and disorder of lipid metabolism
1) Confidence 0.51 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2430569 Disease Relevance 0.62 Pain Relevance 0
Another mechanism that could explain the effect of TV viewing on metabolic syndrome, could be that physical inactivity would reduce the triglyceride uptake from plasma to muscle and it would further lower serum HDL concentrations due to the decrease of lipoprotein lipase (LPL) activity in the skeletal muscle [48].
Negative_regulation (decrease) of LPL in skeletal muscle associated with metabolic syndrome and disorder of lipid metabolism
2) Confidence 0.51 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2430569 Disease Relevance 0.62 Pain Relevance 0
He found that the average LPL activity in rats' skeletal muscles is markedly reduced from 100 percent (SD, 7) to 59 percent (SD, 5) in 6 hours and to 12 percent (SD, 5) in 12 hours [48].
Negative_regulation (reduced) of LPL in skeletal muscles
3) Confidence 0.44 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2430569 Disease Relevance 0.58 Pain Relevance 0
Lipoprotein-lipase deficiency is an uncommon disease, inherited as an autosomal recessive pattern.
Negative_regulation (deficiency) of Lipoprotein-lipase associated with disease
4) Confidence 0.42 Published 1986 Journal Pediatrie Section Abstract Doc Link 3725507 Disease Relevance 0.26 Pain Relevance 0.09
Severe acute necrotizing pancreatitis associated with lipoprotein lipase deficiency in childhood.
Negative_regulation (deficiency) of lipoprotein lipase associated with acute necrotizing pancreatitis
5) Confidence 0.41 Published 2003 Journal J. Pediatr. Surg. Section Title Doc Link 14523833 Disease Relevance 0.29 Pain Relevance 0.18
Body composition analyses from rat trials have demonstrated that TPM inhibits fat deposition while reducing the activity of lipoprotein lipase (LPL) in various white adipose tissue depots.
Negative_regulation (reducing) of lipoprotein lipase in fat associated with obesity
6) Confidence 0.38 Published 2000 Journal Nutrition Section Abstract Doc Link 11054602 Disease Relevance 0.82 Pain Relevance 0.19
Body composition analyses from rat trials have demonstrated that TPM inhibits fat deposition while reducing the activity of lipoprotein lipase (LPL) in various white adipose tissue depots.
Negative_regulation (reducing) of LPL in fat associated with obesity
7) Confidence 0.38 Published 2000 Journal Nutrition Section Abstract Doc Link 11054602 Disease Relevance 0.82 Pain Relevance 0.19
In children this can result from a deficiency of lipoprotein lipase (LPL) or its cofactor, apolipoprotein (apo) C-II.
Negative_regulation (deficiency) of LPL associated with disorder of lipid metabolism
8) Confidence 0.28 Published 2010 Journal Curr Diab Rep Section Body Doc Link PMC2890983 Disease Relevance 2.23 Pain Relevance 0.14
LPL was decreased in high fat diet fed rats, which was reversed by GI262570 but not dose-dependently (data not shown).
Negative_regulation (decreased) of LPL in fat
9) Confidence 0.24 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.10 Pain Relevance 0.23
She has gross chylomicronaemia in the presence of depressed PHLA, which is due to deficiency of lipoprotein lipase.
Negative_regulation (deficiency) of lipoprotein lipase
10) Confidence 0.21 Published 1979 Journal Aust N Z J Med Section Abstract Doc Link 294927 Disease Relevance 0.40 Pain Relevance 0.10
In most of these disorders, pancreatitis is not very common and, with the exception of lipoprotein lipase and apolipoprotein C-II deficiency, is neither the leading nor the clinically most distressing manifestation of the underlying metabolic defect.
Negative_regulation (deficiency) of lipoprotein lipase associated with pancreatitis and disorder of lipid metabolism
11) Confidence 0.15 Published 2001 Journal Pancreatology Section Abstract Doc Link 12120223 Disease Relevance 1.09 Pain Relevance 0.07
In fact, cytokines such as IL-6 increase lipolysis, decrease lipoprotein lipase activity and increase the mobilization of fatty acids in adipose tissue [8].
Negative_regulation (decrease) of lipoprotein lipase in adipose tissue associated with obesity and cytokine
12) Confidence 0.07 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 0.97 Pain Relevance 0.19
We describe the long-time course of 2 brothers with the familial chylomicronemia syndrome caused by identical compound heterozygous mutations in the lipoprotein lipase (LPL) gene with markedly reduced LPL activity.
Negative_regulation (reduced) of lipoprotein lipase associated with syndrome
13) Confidence 0.05 Published 2006 Journal Pancreas Section Abstract Doc Link 16552344 Disease Relevance 1.18 Pain Relevance 0.56
In addition, genes of lipoprotein lipase (LPL), cationic trypsinogen (PRSS1), pancreatic secretory trypsin inhibitor (PSTI), and cystic fibrosis transmembrane conductance regulator (CFTR) were also analyzed.
Negative_regulation (inhibitor) of LPL
14) Confidence 0.05 Published 2010 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 18986377 Disease Relevance 0.07 Pain Relevance 0
In addition, genes of lipoprotein lipase (LPL), cationic trypsinogen (PRSS1), pancreatic secretory trypsin inhibitor (PSTI), and cystic fibrosis transmembrane conductance regulator (CFTR) were also analyzed.
Negative_regulation (inhibitor) of lipoprotein lipase
15) Confidence 0.05 Published 2010 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 18986377 Disease Relevance 0.07 Pain Relevance 0
Pulmonary intravascular macrophages (PIMs) contain a unique electron-dense globular surface-coat which is sensitive to heparin treatment, halothane anesthesia, and the digestive effect of lipolytic lipase (LPL), suggesting that the coat is predominantly composed of lipoproteins.
Negative_regulation (effect) of LPL in PIMs associated with anesthesia and halothane
16) Confidence 0.04 Published 2002 Journal Anat. Rec. Section Abstract Doc Link 11748573 Disease Relevance 0 Pain Relevance 0.15
These extracts restored the activities of enzyme lipoprotein lipase (LPL) that was reduced and glucose-6-phosphatase and lactate dehydrogenase, which were raised in untreated diabetics [36].
Negative_regulation (reduced) of lipoprotein lipase associated with diabetes mellitus
17) Confidence 0.02 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275761 Disease Relevance 1.01 Pain Relevance 0.04
The activity of lipoprotein lipase that determines the catabolism of very low density lipoproteins (VLDL) is decreased by the beta-blocker propranolol and increased by alpha 1-antagonists.
Negative_regulation (decreased) of lipoprotein lipase associated with beta blocker and antagonist
18) Confidence 0.02 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455133 Disease Relevance 0.11 Pain Relevance 0.36

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