INT192809

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 4.06
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SSRP1) chromosome (SSRP1) nucleus (SSRP1)
DNA binding (SSRP1) cytoplasm (SSRP1)
Anatomy Link Frequency
kidney 1
SSRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 8 97.28 Very High Very High Very High
depression 7 80.24 Quite High
aspirin 52 62.44 Quite High
Paresthesia 2 29.40 Quite Low
cINOD 16 19.68 Low Low
imagery 54 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 132 98.08 Very High Very High Very High
Acute Renal Failure 3 96.08 Very High Very High Very High
Apoptosis 40 92.64 High High
Disease 18 87.80 High High
Cancer 270 86.64 High High
Neutropenia 4 86.36 High High
Drug Induced Neurotoxicity 4 85.72 High High
Hypocalcemia 23 83.92 Quite High
Recurrence 8 83.80 Quite High
Tumor Lysis Syndrome 1 82.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite kidney protection in the form of intensive hydration before and after Cisplatin administration severe decrease in calcium levels were observed within 48 hours after the fourth weekly dose without any sign of acute renal failure.
Negative_regulation (decrease) of Cisplatin in kidney associated with acute renal failure
1) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1475608 Disease Relevance 0.83 Pain Relevance 0
The glutathione-mediated cisplatin resistance has been shown to occur through a number of mechanisms including decreased cellular levels of cisplatin [8], inactivation of cisplatin by formation of glutathione-cisplatin adduct [10-12], increased level of DNA repair and DNA tolerance [12,13], and inhibition of some of the mitochondrial alterations associated with apoptotic commitment [41].
Negative_regulation (decreased) of cisplatin associated with tolerance and apoptosis
2) Confidence 0.01 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 0.68 Pain Relevance 0.12
To date, several mechanisms of cisplatin resistance in ovarian cancer cells have been proposed, including decreased cellular uptake and increased cellular efflux of cisplatin [8], inactivation of intracellular cisplatin by glutathione [10-12], and increased levels of DNA repair and DNA tolerance [12,13].
Negative_regulation (inactivation) of cisplatin associated with ovarian cancer and tolerance
3) Confidence 0.01 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 0.91 Pain Relevance 0.05
To date, several mechanisms of cisplatin resistance in ovarian cancer cells have been proposed, including decreased cellular uptake and increased cellular efflux of cisplatin [8], inactivation of intracellular cisplatin by glutathione [10-12], and increased levels of DNA repair and DNA tolerance [12,13].
Negative_regulation (inactivation) of cisplatin associated with ovarian cancer and tolerance
4) Confidence 0.01 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 0.96 Pain Relevance 0.05
The glutathione-mediated cisplatin resistance has been shown to occur through a number of mechanisms including decreased cellular levels of cisplatin [8], inactivation of cisplatin by formation of glutathione-cisplatin adduct [10-12], increased level of DNA repair and DNA tolerance [12,13], and inhibition of some of the mitochondrial alterations associated with apoptotic commitment [41].
Negative_regulation (inactivation) of cisplatin associated with tolerance and apoptosis
5) Confidence 0.01 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 0.68 Pain Relevance 0.12

General Comments

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