INT192840

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.93
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa5) endoplasmic reticulum (Hspa5) nucleus (Hspa5)
response to stress (Hspa5)
Anatomy Link Frequency
brains 1
Hspa5 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 40 54.44 Quite High
Calcium channel 7 7.84 Low Low
ischemia 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
TRP channel 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 99 100.00 Very High Very High Very High
Infection 61 93.40 High High
Apoptosis 13 81.84 Quite High
Death 32 80.64 Quite High
Leukemia 3 75.00 Quite High
Disease 20 63.48 Quite High
Motor Neuron Diseases 1 51.00 Quite High
Lysosomal Storage Diseases 24 50.00 Quite Low
Ganglion Cysts 24 47.20 Quite Low
Starvation 1 36.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(inactive form) is still able to stimulate the translation of ATF4 mRNA, thereby increasing the transcription of BiP or CHOP mRNA, but that enough unphosphorylated-eIF2?
Transcription (transcription) of BiP
1) Confidence 0.47 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.94 Pain Relevance 0
Analysis of message levels for the ER stress genes BiP (grp78), CHOP (Gadd153), calreticulin, and grp58 in cultured microglia, and BiP and CHOP in microglia enriched fractions from infected mouse brains, indicated that FrCasE infection did not induce these ER stress genes either in vitro or in vivo.
Transcription (levels) of grp78 in brains associated with stress and infection
2) Confidence 0.36 Published 2006 Journal Retrovirology Section Abstract Doc Link PMC1475625 Disease Relevance 0.99 Pain Relevance 0.08
One observed discrepancy between the analyses is due to the 78 kDa glucose-regulated protein, which was detected by the SNO-DIGE analysis, but was poorly focused on the 2D gels during the Redox-DIGE analysis.
Transcription (detected) of 78 kDa glucose-regulated protein
3) Confidence 0.15 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2911678 Disease Relevance 0 Pain Relevance 0
The mRNA expression levels of BiP, Hsp40, and Hsp90 were increased up to 1.8-fold, 1.8-fold, and 1.9-fold, respectively, after a 7-d treatment with diltiazem, whereas the mRNA expression levels of Hsp70, GRP94, calnexin, and calreticulin were not changed significantly.
Transcription (expression) of BiP
4) Confidence 0.10 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox