INT192841

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.29
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neutrophil 1
microglia 1
Mela (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 57 99.60 Very High Very High Very High
chemokine 79 95.96 Very High Very High Very High
Arthritis 1 89.60 High High
glial activation 2 78.84 Quite High
Spinal cord 6 73.88 Quite High
Central nervous system 66 64.80 Quite High
cytokine 13 33.84 Quite Low
Inflammation 28 33.48 Quite Low
Kinase C 8 18.24 Low Low
Bile 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 327 100.00 Very High Very High Very High
Apoptosis 16 98.80 Very High Very High Very High
Anaemia 1 93.80 High High
Pneumonia 1 92.16 High High
Disease 46 91.04 High High
Of Sheep Progressive Interstitial Pneumonia 1 91.04 High High
Visna 1 90.80 High High
Viral Meningitis 1 90.12 High High
Arthritis 1 89.60 High High
Immunodeficiency 8 88.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These experiments demonstrated a prolonged CasBrE Env-BiP interaction in cells newly infected with FrCasE [30].
Env Binding (interaction) of
1) Confidence 0.43 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.53 Pain Relevance 0.11
This analysis (figure 1C, left side of upper panel) showed qualitatively different Env banding patterns for FrCasE- versus Fr57E-infected microglia, with CasBrE Env proteins migrating at a lower apparent molecular weight.
Env Binding (migrating) of in microglia
2) Confidence 0.28 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.08 Pain Relevance 0
The entry process begins with the engagement of the Env trimer on the surface of virions by CD4 on the target cell surface.
Env Binding (engagement) of
3) Confidence 0.14 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.21 Pain Relevance 0.04
As for all RVs, the LV genome consists of a positive-strand polyadenylated RNA of about 10 kb and includes three genes; gag, pol, and env organised in the 5' to 3' orientation.
env Binding (organised) of
4) Confidence 0.13 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 1.12 Pain Relevance 0.04
In the case of coreceptor antagonists, the V3 loop of gp120 is the expected site for resistance mutations since this region of the protein is important in mediating the specificity of Env-coreceptor interactions.
Env Binding (interactions) of associated with antagonist
5) Confidence 0.11 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.07 Pain Relevance 0.07
Interactions between the HIV Env protein and CD4 lead to the exposure of the coreceptor-binding site, which includes the third variable loop (V3) of gp120 as well as the bridging sheet, a discontinuous epitope that is formed only after CD4 engagement.
Env Binding (Interactions) of associated with acquired immune deficiency syndrome or hiv infection
6) Confidence 0.10 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.60 Pain Relevance 0.14
Two other HIV-1 proteins, Nef and Env, have been shown to interact with or regulate CXCR4.
Env Binding (interact) of associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.02 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.65 Pain Relevance 0
It is also important to note that HIV-1 Env protein (shed from virus particles or infected cells) can bind to CXCR4 and thereby trigger apoptotic signals.
Env Binding (bind) of associated with acquired immune deficiency syndrome or hiv infection and apoptosis
8) Confidence 0.02 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 1.03 Pain Relevance 0
In principle, GAG-bound monomer and dimer, besides soluble monomer and dimer, can also bind and activate neutrophil receptors.
GAG-bound Binding (bind) of in neutrophil
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0.18

General Comments

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