INT192845

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.15
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 32 99.70 Very High Very High Very High
Central nervous system 61 90.56 High High
Glutamate receptor 20 88.80 High High
cytokine 23 55.28 Quite High
opioid receptor 1 52.40 Quite High
Opioid 1 46.32 Quite Low
Spinal cord 7 42.40 Quite Low
Inflammation 46 32.00 Quite Low
Demyelination 5 14.52 Low Low
Multiple sclerosis 121 5.44 Low Low
Disease Link Frequency Relevance Heat
Stress 46 99.96 Very High Very High Very High
Multiple Sclerosis 221 96.92 Very High Very High Very High
Targeted Disruption 5 92.32 High High
Infection 61 64.00 Quite High
Leukemia 3 50.00 Quite Low
Toxicity 1 46.80 Quite Low
Disease 116 41.08 Quite Low
INFLAMMATION 48 32.00 Quite Low
Demyelinating Disease 7 14.52 Low Low
Autoimmune Disease 43 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, whether targeted stimulation of ER?
Negative_regulation (targeted) of Positive_regulation (stimulation) of ER
1) Confidence 0.35 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.41 Pain Relevance 0.07
Whether this is due to lower cellular viral proteins levels is not clear, however, even fewer higher order structures may prevent the induction of ER stress in this cell type.
Spec (may) Negative_regulation (prevent) of Positive_regulation (induction) of ER associated with stress
2) Confidence 0.12 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.74 Pain Relevance 0
In fact, the mutations that reduced glutamate affinity also impaired ER export, whereas a mutant that facilitated ligand-induced conformational change had an accelerated ER export.
Negative_regulation (impaired) of Positive_regulation (accelerated) of ER associated with glutamate
3) Confidence 0.03 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.24

General Comments

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