INT192851

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.12
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
macrophages 1
granulocyte 1
nucleus 1
F4/80 1
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 148 100.00 Very High Very High Very High
ischemia 21 97.44 Very High Very High Very High
Central nervous system 33 89.76 High High
Arthritis 5 83.16 Quite High
tolerance 27 79.68 Quite High
cytokine 95 75.76 Quite High
Analgesic 2 75.04 Quite High
chemokine 15 55.64 Quite High
agonist 32 44.00 Quite Low
Spinal cord 3 40.20 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 158 100.00 Very High Very High Very High
Apoptosis 15 99.74 Very High Very High Very High
Cv Unclassified Under Development 14 97.44 Very High Very High Very High
Infection 61 97.24 Very High Very High Very High
Cancer 230 95.40 Very High Very High Very High
Adhesions 4 90.32 High High
Injury 99 88.72 High High
Ileus 9 88.60 High High
Hemorrhagic Shock 6 86.88 High High
Disease 22 84.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LKB1 was phosphorylated by IL-6 at Ser431, although the state of phosphorylation of this kinase did not significantly affect LKB1 catalytic activity or its cellular location, as described previously (36).
Phosphorylation (phosphorylated) of IL-6
1) Confidence 0.68 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.33 Pain Relevance 0.06
AS160 was phosphorylated by IL-6 and insulin individually, and when combined, an additive effect was produced at 3 h of IL-6 treatment.
Phosphorylation (phosphorylated) of IL-6
2) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.12 Pain Relevance 0.10
Furthermore, direct inhibition of AMPK activity with either compound C or siRNA in the presence of IL-6 blocked phosphorylation of AS160 and impeded glucose uptake.
Phosphorylation (presence) of IL-6
3) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.22 Pain Relevance 0.06
, IL-6, and IL-10 exclusively through TTP phosphorylation such as in murine bone marrow-derived macrophages [126].These above studies and others offer strong evidence for the p38 MAPK regulation of ARE-mRNA stability and the association with loss of TTP function.
Phosphorylation (phosphorylation) of IL-6 in macrophages
4) Confidence 0.12 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.32 Pain Relevance 0.12
Importantly, the current findings showing a lack of gene expression changes in microglia in response to NV infection are consistent with our previous analyses that have failed to show evidence of biochemical (e.g., iNOS, esterases, apoptosis, proteases, phosphorylations) or inflammatory changes (e.g., altered expression of MHC, CD11b, CD80, CD86, IL-1, IL-6, TNF alpha, F4/80, etc.) in microglia in vivo as early components of the pathogenic process (cf [7]).
Phosphorylation (phosphorylations) of IL-6 in F4/80 associated with inflammation, apoptosis and infection
5) Confidence 0.09 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.45 Pain Relevance 0.18
Similar to IL-6 and IL-10, Pam3Cys significantly promoted the expression, phosphorylation, and nucleus translocation of Stat3 in B16 cells (Fig. 2D–F).
Phosphorylation (phosphorylation) of IL-6 in nucleus
6) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.18 Pain Relevance 0.06
The cellular responses after warm ischemia were preceded by the molecular activation of nuclear factor kappa B, upregulation of granulocyte colony-stimulating factor and IL-6 mRNA and phosphorylation of the downstream signaling and transcription factor Stat3 [59].
Phosphorylation (phosphorylation) of IL-6 mRNA in granulocyte associated with ischemia
7) Confidence 0.01 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 1.50 Pain Relevance 0.24

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