INT192857

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.74
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2r1a) chromosome segregation (Ppp2r1a) chromosome (Ppp2r1a)
cytoplasm (Ppp2r1a)
Anatomy Link Frequency
brain 1
PP2A 1
microglia 1
Ppp2r1a (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 5 86.64 High High
ischemia 36 77.60 Quite High
Migraine 1 74.40 Quite High
agonist 32 68.28 Quite High
Dopamine 69 50.00 Quite Low
dopamine receptor 10 46.04 Quite Low
member 8 2 29.96 Quite Low
monoamine 3 18.68 Low Low
Central nervous system 66 5.00 Very Low Very Low Very Low
antagonist 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 94 98.48 Very High Very High Very High
Death 11 97.28 Very High Very High Very High
Cancer 22 89.24 High High
Disease 56 87.40 High High
Hypoxia 7 78.64 Quite High
Cv Unclassified Under Development 35 77.60 Quite High
Ataxia 33 77.44 Quite High
Migraine With Aura 1 76.00 Quite High
Stress 109 65.76 Quite High
Infection 125 64.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gag immunoblotting (figure 1C, lower panel) showed the presence of glyco-gag and pr65gag expression in all FrCasE- and Fr57E-infected microglia, at levels that did not differ significantly between equivalent cell extracts.
Gene_expression (expression) of pr65gag in microglia
1) Confidence 0.47 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.06 Pain Relevance 0
The relative levels of Env protein being expressed in the various cultures appeared to be somewhat variable in contrast to the levels of pr65gag (see below), which were more consistent between cultures.
Gene_expression (levels) of pr65gag
2) Confidence 0.36 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0 Pain Relevance 0
Also, it has been reported that ROS inhibit protein phosphatase 2A (PP2A) (41, 42), phosphatase activity that has been implicated in regulation of 4E-BP1 phosphorylation (7, 30, 43). 4E-BP1 phosphorylation at Ser64, but not Thr69, is induced by ROS (44).
Neg (inhibit) Gene_expression (inhibit) of PP2A in PP2A
3) Confidence 0.13 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.22 Pain Relevance 0.04
The significance of the gene expression trends of AMD1, BNIP3, GRB10, MARCKSL1, NGRAP1, ODC1, PPP2CB, PPP2R1A, SLC25A4, SLC25A6, and WDR45L that function in cell growth or cell death/survival were not straightforward.
Gene_expression (expression) of PPP2R1A associated with death
4) Confidence 0.12 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2956710 Disease Relevance 0.91 Pain Relevance 0
Apropos of this fact, a plausible link between cAMP and Akt might be PP2A, a phosphatase which can be activated by PKA and is responsible for the dephosphorylation of Akt [10], [37].
Gene_expression (Apropos) of PP2A
5) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2467486 Disease Relevance 0 Pain Relevance 0.03
SCA12 is caused by a CAG repeat expansion that is not transcribed to polyglutamine and is speculated to affect the expression of the gene PPP2R2B, which encodes a brain-specific regulatory subunit of protein phosphatase PP2A (Holmes et al 1999).
Gene_expression (expression) of phosphatase PP2A in brain
6) Confidence 0.02 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.55 Pain Relevance 0.12

General Comments

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