INT19286

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Context Info
Confidence 0.46
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.12
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cacna1c) nucleus (Cacna1c) transmembrane transport (Cacna1c)
cytoplasm (Cacna1c)
Anatomy Link Frequency
plasma 2
blood 1
RBCs 1
neurons 1
respiratory 1
Cacna1c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 7 99.14 Very High Very High Very High
cva 5 97.96 Very High Very High Very High
isoflurane 5 97.64 Very High Very High Very High
Inflammation 13 97.44 Very High Very High Very High
Enkephalin 1 93.04 High High
adenocard 2 92.44 High High
MU agonist 6 91.80 High High
dorsal root ganglion 6 88.48 High High
Paracetamol 1 84.64 Quite High
anesthesia 4 81.84 Quite High
Disease Link Frequency Relevance Heat
Poisoning 35 99.54 Very High Very High Very High
Pernicious Anemia 5 99.28 Very High Very High Very High
Body Weight 3 98.40 Very High Very High Very High
Hemorrhage 5 97.96 Very High Very High Very High
Arthritis 51 97.44 Very High Very High Very High
INFLAMMATION 15 97.44 Very High Very High Very High
Reticulocytosis 5 97.32 Very High Very High Very High
Syndrome 5 97.16 Very High Very High Very High
Rupture 1 97.08 Very High Very High Very High
Alcohol Addiction 5 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chemoprotection against both MNNG and MMS correlated with reduced RBC fragility (R = 0.97 and 0.70, respectively).
Negative_regulation (reduced) of RBC
1) Confidence 0.46 Published 1991 Journal Chem. Biol. Interact. Section Abstract Doc Link 2040020 Disease Relevance 0.53 Pain Relevance 0.08
In agreement with these observations, arterio-venous transit-time and laser-Doppler flowmetry consistently showed a significant reduction of the RBC and plasma blood speed under alpha-chloralose relative to isoflurane.
Negative_regulation (reduction) of RBC in blood associated with isoflurane
2) Confidence 0.38 Published 2010 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 20204771 Disease Relevance 0 Pain Relevance 0.47
From the results it is clear that the decrease in RBC count and haemoglobin level represents the anemic condition in arthritic rats.
Negative_regulation (decrease) of RBC associated with arthritis
3) Confidence 0.18 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2978115 Disease Relevance 1.05 Pain Relevance 0.11
When the RBCs were incubated with NSAIDs, the drugs attained maximum levels within RBC, and the levels were then reduced.
Negative_regulation (reduced) of RBC in RBCs associated with cinod
4) Confidence 0.16 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 12913268 Disease Relevance 0.16 Pain Relevance 0.59
As for RBC cholinesterase (Table 7), the significant predictors are, again, years of pesticide use (p = 0.037) and health symptoms reported in the survey (p = 0.029). the number of years using pesticides gives an index of the length and possible extent of exposure, which has been shown to lower RBC cholinesterase levels.
Negative_regulation (lower) of RBC
5) Confidence 0.12 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.24 Pain Relevance 0
It should be noted, however, that RBC cholinesterase is more difficult to measure and is depressed more slowly than plasma cholinesterase.
Negative_regulation (depressed) of RBC in plasma
6) Confidence 0.12 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.07 Pain Relevance 0.03
Meanwhile, RBC cholinesterase levels are lowered by hemolytic and pernicious anemia, recovery from hemorrhage, and reticulocytosis.
Negative_regulation (lowered) of RBC associated with pernicious anemia, reticulocytosis and cva
7) Confidence 0.09 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.68 Pain Relevance 0.05
Organophosphate poisoning can be indicated by a decrease in RBC cholinesterase.
Negative_regulation (decrease) of RBC associated with poisoning
8) Confidence 0.09 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.51 Pain Relevance 0.07
In addition, certain conditions other than pesticide exposure can lower plasma and RBC cholinesterase levels, confounding interpretation of test results.
Negative_regulation (lower) of RBC in plasma
9) Confidence 0.09 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.59 Pain Relevance 0.04
Although the respiratory symptoms of exposed residents were consistent with those in previous reports of Halon exposure (Brooks et al. 1985; De La Hoz 1999; Holness and House 1992; Kaufman et al. 1992), we wondered why there were decreases in RBC and HB.
Negative_regulation (decreases) of RBC in respiratory
10) Confidence 0.02 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665423 Disease Relevance 0.68 Pain Relevance 0.06
Furthermore, DPDPE produced a greater inhibition of N-, P/Q-, and L-type I(Ca) in IB(4)-negative than IB(4)-positive neurons.
Negative_regulation (inhibition) of L-type I in neurons
11) Confidence 0.01 Published 2008 Journal Neuroscience Section Abstract Doc Link 18434033 Disease Relevance 0.62 Pain Relevance 0.72

General Comments

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